Pemetrexed 2Na | Multitargeted antifolate

CAS:
357166-29-1
Catalog Number:
10-2162
Activity:
Multi-targeted antifolate
Chemical Name:
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, disodium salt
Molecular Weight:
597.49
Molecular Formula:
C20H19N5O6 • 2Na • 7H2O
Solubility:
Soluble in Water (up to 100 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC and HPLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 1 year as supplied. Solutions in distilled water may be stored at -20° for up to 31month.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
10 mg$70.00
50 mg$240.00
This product is also available in the following library:

Pemetrexed (357166-29-1) is a multi-targeted antifolate with antitumor activity. It potently inhibits folate-dependent enzymes involved in both purine and pyrimidine synthesis including thymidylate synthase (Ki = 109 nM), dihydrofolate reductase (Ki = 7 nM), glycinamide ribonucleotide formyltransferase (Ki = 9.3 μM), and aminoimidazole carboxamide ribonucleotide formyltransferase (Ki = 3.6 μM).1 A clinically useful anticancer agent.2 Indirectly activates the metabolic kinase AMPK and consequently influences the mTORC1 pathway in human carcinomas.3 Activation of AMPK is associated with pemetrexed resistance.4 Induces G0/G1-phase cell cycle arrest in esophageal squamous cell carcinoma cells.5

References/Citations:

1) Shih et al. (1997), LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes; Cancer Res. 57 1116
2) Hanauske et al. (2001), Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors; Oncologist 6 363
3) Rothbart et al. (2010), Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas; Cancer Res. 70 10299
4) Qin et al. (2019), AMPK activation induced in pemetrexed-treated cells is associated with development of drug resistance independently of target enzyme expression; Mol. Oncol. 13 1419
5) Li et al. (2019), Pemetrexed exerts anticancer effects by inducing G0/G1-phase cell cycle arrest and activating the NOXA/Mcl-1 axis in human esophageal squamous cell carcinoma cells; Oncol. Lett. 17 1851

CAS:
357166-29-1
Catalog Number:
10-2162
Activity:
Multi-targeted antifolate
Chemical Name:
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, disodium salt
Molecular Weight:
597.49
Molecular Formula:
C20H19N5O6 • 2Na • 7H2O
Solubility:
Soluble in Water (up to 100 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC and HPLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 1 year as supplied. Solutions in distilled water may be stored at -20° for up to 31month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

20% OFF

For Postdoc
Customers!