PF-06840003 | IDO1 inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $210.00 |
PF-06840003 (198474-05-4) is a potent (IC50 = 150 and 410 nM via two methods) and selective inhibitor of Indoleamine-2,3-dioxygenase (IDO1).1 In mice with syngeneic tumor grafts, it reduced intratumoral kynurenine levels by over 80%, inhibited tumor growth as monotherapy, and increased the efficacy of anti-PD-L1 therapy.2 PF-06840003 treatment combined with GM-CSF-secreting allogenic pancreatic tumor cell vaccine (GVAX) resulted in increased antitumor efficacy in a murine model of pancreatic ductal adenocarcinoma.3 PF-06840003 rescued hippocampal synaptic plasticity and memory function in preclinical models of amyloid and tau pathology via restoration of neuronal metabolic support.4
References/Citations:
1) Crosignani et al. (2017), Discovery of a Novel and Selective Indoleamine-2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EROS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate; J. Med. Chem. 60 9617
2) Gomes et al. (2018), Characterization of the Selective Indoleamine-2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy; Mol. Cancer Ther. 9 2530
3) Blair et al. (2019), IDO1 inhibition potentiates vaccine-induced immunity against pancreatic adenocarcinoma; J. Clin. Invest. 129 1742
4) Minhas et al. (2024), Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies; Science 385 eabm6131
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
PF-06840003 (198474-05-4) is a potent (IC50 = 150 and 410 nM via two methods) and selective inhibitor of Indoleamine-2,3-dioxygenase (IDO1).1 In mice with syngeneic tumor grafts, it reduced intratumoral kynurenine levels by over 80%, inhibited tumor growth as monotherapy, and increased the efficacy of anti-PD-L1 therapy.2 PF-06840003 treatment combined with GM-CSF-secreting allogenic pancreatic tumor cell vaccine (GVAX) resulted in increased antitumor efficacy in a murine model of pancreatic ductal adenocarcinoma.3 PF-06840003 rescued hippocampal synaptic plasticity and memory function in preclinical models of amyloid and tau pathology via restoration of neuronal metabolic support.4
References/Citations:
1) Crosignani et al. (2017), Discovery of a Novel and Selective Indoleamine-2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EROS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate; J. Med. Chem. 60 9617
2) Gomes et al. (2018), Characterization of the Selective Indoleamine-2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy; Mol. Cancer Ther. 9 2530
3) Blair et al. (2019), IDO1 inhibition potentiates vaccine-induced immunity against pancreatic adenocarcinoma; J. Clin. Invest. 129 1742
4) Minhas et al. (2024), Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies; Science 385 eabm6131
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