Size: | Price | Quantity | |
---|---|---|---|
5 mg | $40.00 | ||
25 mg | $135.00 |
PF-4708671 dihydrochloride (125517-76-0 free base) is a cell permeable inhibitor of p70 ribosomal S6 kinase 1 (Ki = 20 nM; IC50 = 160 nM).1 Selective against 87 kinases including 13 other AGC family members. It enhanced cell death induced by glucose deprivation in breast cancer cells2 and inhibited cell migration in triple-negative breast cancer cells3. PF-4708671 inhibited cell proliferation and invasiveness in multiple non-small cell lung cancer cell lines and inhibited tumorigenesis in mice.4 It induced AMPK phosphorylation and activation independently of p70SK1 via specific inhibition of mitochondrial respiratory chain complex I.5 PF-4708671 displayed protective effects in a mouse model of cerebral ischemia-reperfusion injury.6
References/Citations:
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PF-4708671 dihydrochloride (125517-76-0 free base) is a cell permeable inhibitor of p70 ribosomal S6 kinase 1 (Ki = 20 nM; IC50 = 160 nM).1 Selective against 87 kinases including 13 other AGC family members. It enhanced cell death induced by glucose deprivation in breast cancer cells2 and inhibited cell migration in triple-negative breast cancer cells3. PF-4708671 inhibited cell proliferation and invasiveness in multiple non-small cell lung cancer cell lines and inhibited tumorigenesis in mice.4 It induced AMPK phosphorylation and activation independently of p70SK1 via specific inhibition of mitochondrial respiratory chain complex I.5 PF-4708671 displayed protective effects in a mouse model of cerebral ischemia-reperfusion injury.6
References/Citations:
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