Phalloidin | Actin-binding agent

CAS:
 17466-45-4
Catalog Number:
 10-2359
Phalloidin chemical structure

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Phalloidin (17466-45-4) is a bicyclic heptapeptide that binds to filamentous actin, promoting and stabilizing polymerization.1,2 Reverses actin destabilization by cytochalasin B2, and modifies branch formation / deformation mediated by Arp2/3 complex3. Immobilized phalloidin can be used for biochemical isolation of F-actin and F-actin binding proteins.4

References/Citations:

  1. Coluccio and Tilney (1984), Phalloidin enhances actin assembly by preventing monomer dissociation; J. Cell Biol. 99 529
  2. Cooper. (1987), Effects of cytochalasin and phalloidin on actin; J. Cell Biol. 105 1473
  3. Mahaffy et al. (2006), Kinetics of the formation and dissociation of actin filament branches mediated by Arp2/3 complex; Biophys. J. 91 3519
  4. Samwer et al. (2013), The nuclear F-actin interactome of Xenopus oocytes reveals an actin-bundling kinesin that is essential for meiotic cytokinesis; EMBO J. 32 1886
17466-45-4, Phalloidin, Phalloidin supplier
CAS:
17466-45-4
Catalog Number:
10-2359
Activity:
Actin-binding agent
Chemical Names:
(1S,14R,18S,20S,23S,28S,31S,34R)-28-[(2R)-2,3-dihydroxy-2-methylpropyl]-18-hydroxy-34-[(1S)-1-hydroxyethyl]-23,31-dimethyl-12-thia-10,16,22,25,27,30,33,36-octazapentacyclo[12.11.11.03,11.04,9.016,20]hexatriaconta-3(11),4,6,8-tetraene-15,21,24,26,29,32,35-heptone
Molecular Weight:
788.87
Molecular Formula:

C35H48N8O11S

Solubility:
Soluble in DMSO (10 mg/ml); Water (1 mg/ml)
Physical Properties:
White solid
Purity:

>95% HPLC
MS: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO or water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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Phalloidin (17466-45-4) is a bicyclic heptapeptide that binds to filamentous actin, promoting and stabilizing polymerization.1,2 Reverses actin destabilization by cytochalasin B2, and modifies branch formation / deformation mediated by Arp2/3 complex3. Immobilized phalloidin can be used for biochemical isolation of F-actin and F-actin binding proteins.4

References/Citations:

  1. Coluccio and Tilney (1984), Phalloidin enhances actin assembly by preventing monomer dissociation; J. Cell Biol. 99 529
  2. Cooper. (1987), Effects of cytochalasin and phalloidin on actin; J. Cell Biol. 105 1473
  3. Mahaffy et al. (2006), Kinetics of the formation and dissociation of actin filament branches mediated by Arp2/3 complex; Biophys. J. 91 3519
  4. Samwer et al. (2013), The nuclear F-actin interactome of Xenopus oocytes reveals an actin-bundling kinesin that is essential for meiotic cytokinesis; EMBO J. 32 1886

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