Phenoxybenzamine HCl | Calmodulin antagonist
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 100 mg | $30.00 | ||
| 500 mg | $90.00 |
Phenoxybenzamine HCl (63-92-3) binds to and inhibits calmodulin in a calcium-dependent and irreversible manner (IC50= ca. 1 μM)1. A classical irreversible α adrenergic antagonist2. Phenoxybenzamine HCl is a useful tool for irreversible inhibition of calmodulin. Cell permeable.
References/Citations
1) Earl et al. (1984), Interaction of alpha adrenergic antagonists with calmodulin; Life Sci., 355 525
2) Frang et al. (2001), Phenoxybenzamine binding reveals the helical orientation of the third transmembrane domain of adrenergic receptors; J. Biol. Chem., 276 31279
3) James et al. (2009), Inhibition of nitric oxide-activated guanylylcyclase by calmodulin antagonists; Br. J. Pharmacol., 158 1454
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Phenoxybenzamine HCl (63-92-3) binds to and inhibits calmodulin in a calcium-dependent and irreversible manner (IC50= ca. 1 μM)1. A classical irreversible α adrenergic antagonist2. Phenoxybenzamine HCl is a useful tool for irreversible inhibition of calmodulin. Cell permeable.
References/Citations
1) Earl et al. (1984), Interaction of alpha adrenergic antagonists with calmodulin; Life Sci., 355 525
2) Frang et al. (2001), Phenoxybenzamine binding reveals the helical orientation of the third transmembrane domain of adrenergic receptors; J. Biol. Chem., 276 31279
3) James et al. (2009), Inhibition of nitric oxide-activated guanylylcyclase by calmodulin antagonists; Br. J. Pharmacol., 158 1454
Related products
-
Sunitinib malate | VEGFR, PDGFR kinase inhibitor
From $60.00CAS:341031-54-7Catalog Number:10-1078Activity:VEGFR, PDGFR kinase inhibitorAlternate Names:SU-11248Chemical Name:N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide malateMolecular Weight:532.57Molecular Formula:C22H27FN4O4 C4H6O5Solubility:Soluble in DMSO (up to 13 mg/ml).Physical Properties:Orange solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Nifedipine | L-type Ca channel blocker
From $40.00CAS:21829-25-4Catalog Number:10-1116Activity:L-type Ca channel blockerChemical Name:2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl esterMolecular Weight:346.34Molecular Formula:C17H18N2O6Solubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:Yellow solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions are not stable and must be used within one working day.Shipping Code:RT -
Cyclosporin A | Inhibits mitochondrial permeability pore opening
From $50.00CAS:59865-13-3Catalog Number:10-1119Activity:Inhibits mitochondrial permeability pore openingMolecular Weight:1202.65Molecular Formula:C62H111N11O12Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:White solidPurity:99% by TLCStorage Temperature:-20°CStability:Stable for 3 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
