Phenylacetyl-L-glutamine | Bioactive gut microbial metabolite
CAS:
28047-15-6
Catalog Number:
10-5706
Activity:
Bioactive gut microbial metabolite
Chemical Names:
(S)-5-Amino-5-oxo-2-(2-phenylacetamido)pentanoic acid
Alternate Name:
N-Phenylacetylglutamine, Phenylacetylglutamine;
PhenylAc-Gln-OH; NSC-203800; PAG
PhenylAc-Gln-OH; NSC-203800; PAG
Molecular Weight:
264.28
Molecular Formula:
C13H16N2O4
Solubility:
Soluble in DMSO (45 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $48.00 | ||
| 50 mg | $170.00 |
Phenylacetyl-L-glutamine (28047-15-6) is a microbial-mammalian host co-metabolite which increases with age1 and especially in extreme longevity2. Gut-microbiota-dependent PAG is associated with cardiovascular disease pathogenesis3 via action at adrenergic receptors4. Plasma PAG levels may be a valuable indicator for predicting coronary in-stent restenosis.5
Refences/Citations:
- Swann et al. (2013) Microbial-mammalian cometabolites dominate the age-associated urinary metabolic phenotype in Taiwanese and American populations; J. Proteome Res. 12 3166
- Collino et al. (2013) Metabolic signatures of extreme longevity in northern Italian centenarians reveal a complex remodeling of lipids, amino acids, and gut microbiota metabolism; PLoS One 8 1
- Romano et al. (2022) Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure; Circ. Heart Fail. Dec 16 e009972 online ahead of print
- Nemet et al. (2020) A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors; Cell 180 862
- Yua et al. (2022) Prognostic value of plasma phenylalanine and gut microbiota-derived metabolite phenylacetylglutamine in coronary in-stent restenosis; Front. Cardiovasc. Med. 9 944155
CAS:
28047-15-6
Catalog Number:
10-5706
Activity:
Bioactive gut microbial metabolite
Chemical Names:
(S)-5-Amino-5-oxo-2-(2-phenylacetamido)pentanoic acid
Alternate Name:
N-Phenylacetylglutamine, Phenylacetylglutamine;
PhenylAc-Gln-OH; NSC-203800; PAG
PhenylAc-Gln-OH; NSC-203800; PAG
Molecular Weight:
264.28
Molecular Formula:
C13H16N2O4
Solubility:
Soluble in DMSO (45 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Safety Data Sheet:
N/A
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Phenylacetyl-L-glutamine (28047-15-6) is a microbial-mammalian host co-metabolite which increases with age1 and especially in extreme longevity2. Gut-microbiota-dependent PAG is associated with cardiovascular disease pathogenesis3 via action at adrenergic receptors4. Plasma PAG levels may be a valuable indicator for predicting coronary in-stent restenosis.5
Refences/Citations:
- Swann et al. (2013) Microbial-mammalian cometabolites dominate the age-associated urinary metabolic phenotype in Taiwanese and American populations; J. Proteome Res. 12 3166
- Collino et al. (2013) Metabolic signatures of extreme longevity in northern Italian centenarians reveal a complex remodeling of lipids, amino acids, and gut microbiota metabolism; PLoS One 8 1
- Romano et al. (2022) Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure; Circ. Heart Fail. Dec 16 e009972 online ahead of print
- Nemet et al. (2020) A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors; Cell 180 862
- Yua et al. (2022) Prognostic value of plasma phenylalanine and gut microbiota-derived metabolite phenylacetylglutamine in coronary in-stent restenosis; Front. Cardiovasc. Med. 9 944155
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