Piericidin A | Mitochondrial complex I inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 200 µg | $45.00 | ||
| 1 mg | $140.00 |
Piericidin A (2738-64-9) is a potent inhibitor of the mitochondrial and bacterial type I NADH-ubiquinone oxidoreductase (complex I).1 Piericidin A is a ubiquinone analog which binds to the ubiquinone binding site of the enzyme.2 It is an extremely useful tool for exploring the role of complex I in mitochondrial function in both normal and pathophysiology.3-5 Prevents upregulation of GRP78 and induces cell death in glucose-deprived, etoposide-resistant HT-29 cells (IC50=7.7 nM).6
References/Citations:
1) Fato et al. (2009), Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species; Biochim. Biophys. Acta, 1787 384
2) Zhou and Fenical (2016), The unique chemistry and biology of the piericidins; J. Antibiot. (Tokyo), 69 582
3) Bongard et al. (2015), The effects of mitochondrial complex I blockade on ATP and permeability in rat pulmonary microvascular endothelial cells in culture (PMVEC) are overcome by coenzyme Q1 (CoQ1); Free Radic. Biol. Med., 79 69
4) Lee et al. (2013), Isoniazid-induced cell death is precipitated by underlying mitochondrial complex I dysfunction in mouse hepatocytes; Free Radic. Biol. Med., 65 584
5) Choi et al. (2011), Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a parkinson’s disease model; J. Cell Biol., 192 873
6) Hwang et al. (2008), Etoposide-resistant HT-29 human colon carcinoma cells during glucose deprivation are sensitive to piericidin A, a GRP78 down regulator; J. Cell Physiol., 215 243
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Piericidin A (2738-64-9) is a potent inhibitor of the mitochondrial and bacterial type I NADH-ubiquinone oxidoreductase (complex I).1 Piericidin A is a ubiquinone analog which binds to the ubiquinone binding site of the enzyme.2 It is an extremely useful tool for exploring the role of complex I in mitochondrial function in both normal and pathophysiology.3-5 Prevents upregulation of GRP78 and induces cell death in glucose-deprived, etoposide-resistant HT-29 cells (IC50=7.7 nM).6
References/Citations:
1) Fato et al. (2009), Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species; Biochim. Biophys. Acta, 1787 384
2) Zhou and Fenical (2016), The unique chemistry and biology of the piericidins; J. Antibiot. (Tokyo), 69 582
3) Bongard et al. (2015), The effects of mitochondrial complex I blockade on ATP and permeability in rat pulmonary microvascular endothelial cells in culture (PMVEC) are overcome by coenzyme Q1 (CoQ1); Free Radic. Biol. Med., 79 69
4) Lee et al. (2013), Isoniazid-induced cell death is precipitated by underlying mitochondrial complex I dysfunction in mouse hepatocytes; Free Radic. Biol. Med., 65 584
5) Choi et al. (2011), Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a parkinson’s disease model; J. Cell Biol., 192 873
6) Hwang et al. (2008), Etoposide-resistant HT-29 human colon carcinoma cells during glucose deprivation are sensitive to piericidin A, a GRP78 down regulator; J. Cell Physiol., 215 243
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