Pifithrin α | p53 inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $195.00 |
Pifithrin α (63208-82-2) is a reversible inhibitor of p53-mediated transcription and p53-dependent apoptosis. Enhances survival after genotoxic stress and protects against chemotherapeutic side-effects in mice.1,2 Supresses self-renewal of embryonic stem cells.5 Pfithrin α protects against neuronal death in models of stroke and neurodegenerative disease.3 AhR agonist.4
References/Citations:
1) Komarov et al. (1999), A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy; Science, 285 1733
2) Komarova and Gudkov et al. (2000), Suppression of p53: a new approach to overcome the side effects of antitumor therapy; Biochemistry, 65 41
3) Culmsee et al. (2001), A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid-peptide; J. Neurochem., 77 220
4) Hoagland et al. (2005), The p53 inhibitor pifithrin-α is a potent agonist of the aryl hydrocarbon receptor; J. Pharmacol. Exp. Ther., 314 630
5) Abdelalim and Tooyama (2012), The p53 inhibitor, pifithrin-α, suppresses self-renewal of embryonic stem cells; Biochem. Biophys. Res. Comm., 420 605
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Pifithrin α (63208-82-2) is a reversible inhibitor of p53-mediated transcription and p53-dependent apoptosis. Enhances survival after genotoxic stress and protects against chemotherapeutic side-effects in mice.1,2 Supresses self-renewal of embryonic stem cells.5 Pfithrin α protects against neuronal death in models of stroke and neurodegenerative disease.3 AhR agonist.4
References/Citations:
1) Komarov et al. (1999), A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy; Science, 285 1733
2) Komarova and Gudkov et al. (2000), Suppression of p53: a new approach to overcome the side effects of antitumor therapy; Biochemistry, 65 41
3) Culmsee et al. (2001), A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid-peptide; J. Neurochem., 77 220
4) Hoagland et al. (2005), The p53 inhibitor pifithrin-α is a potent agonist of the aryl hydrocarbon receptor; J. Pharmacol. Exp. Ther., 314 630
5) Abdelalim and Tooyama (2012), The p53 inhibitor, pifithrin-α, suppresses self-renewal of embryonic stem cells; Biochem. Biophys. Res. Comm., 420 605
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