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Pifithrin alpha | p53 inhibitor

Pifithrin α (63208-82-2) is a reversible inhibitor of p53-mediated transcription and p53-dependent apoptosis. Enhances survival after genotoxic stress and protects against chemotherapeutic side-effects in mice.1,2 Supresses self-renewal of embryonic stem cells.5 Pfithrin α protects against neuronal death in models of stroke and neurodegenerative disease.3 AhR agonist.4

1) Komarov et al. (1999), A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy; Science, 285 1733
2) Komarova and Gudkov et al. (2000), Suppression of p53: a new approach to overcome the side effects of antitumor therapy; Biochemistry, 65 41
3) Culmsee et al. (2001), A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid-peptide; J. Neurochem., 77 220
4) Hoagland et al. (2005), The p53 inhibitor pifithrin-α is a potent agonist of the aryl hydrocarbon receptor; J. Pharmacol. Exp. Ther., 314 630
5) Abdelalim and Tooyama (2012), The p53 inhibitor, pifithrin-α, suppresses self-renewal of embryonic stem cells; Biochem. Biophys. Res. Comm., 420 605

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Catalog#  10-2480

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Catalog Number:
p53 inhibitor
Alternate Names:
Chemical Name:
1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone á HBr
Molecular Weight:
Molecular Formula:
C16H18N2OS HBr
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
98% by TLC
NMR (Conforms)
Storage Temperature:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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