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Pioglitazone HCl | PPAR gamma agonist

Pioglitazone (112529-15-4) is a clinically useful antidiabetic drug.1 It is a selective agonist of the human peroxisome proliferator-activated receptor γ 1 (PPARγ1; EC50 = 490 nM2, 550 nM3) with weak agonist activity at PPARα and no activity at PPARδ.2  Inhibits mitochondrial pyruvate metabolism and glucose production in hepatocytes.4 Suppresses production of inflammatory cytokines and shows antidepressant-like activity in mouse models.5

References/Citations
1) Merck 14:7452
2) Sakamoto et al. (2000), Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone; Biochem. Biophys. Res. Commun., 278 704
3) Wilson et al. (2000), The PPARs: From Orphan Receptors to Drug Discovery; J. Med. Chem., 43 527
4) Shannon et al. (2017), Pioglitazone Inhibits Mitochondrial Pyruvate Metabolism and Glucose Production in Hepatocytes; FEBS J., 284 451
5) Zhao et al. (2016), The Antidepressant-Like Effects of Pioglitazone in a Chronic Mild Stress Mouse Model Are Associated With PPARγ-Mediated Alteration of Microglial Activation Phenotypes; Neuroinflamm., 13 259

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Focus Biomolecules cell signaling reagent supplier, structure of Pioglitazone | PPAR gamma agonist | CAS 112529-15-4

Catalog#  10-1010

$30.00
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CAS:
112529-15-4
Catalog Number:
10-1010
Activity:
PPARγ agonist
Chemical Name:
5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione hydrochloride
Molecular Weight:
392.90
Molecular Formula:
C19H20N2O3S HCl
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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