Piperlongumine | Glutathione sponge / Increases ROS levels
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 20 mg | $30.00 | ||
| 100 mg | $120.00 |
Piperlongumine (20069-09-4) elevates cellular levels of reactive oxygen species selectively in cancer cell lines.1 Irreversible glutathionylation leading to depletion of cellular glutathione is associated with its cellular toxicity.2 Piperlongumine does not appear to have any effect on normal cells. Displays anti-tumor effects in a mouse xenograft tumor model as well as in spontaneously formed malignant breast tumors in mice.1 Elevation of ROS levels in response to piperlongumine may be due to inhibition of ubiquitin-proteasome system at a pre-proteasomal step.3
References/Citations:
1) Raj et al. (2011), Selective killing of cancer cells by a small molecule targeting the stress response to ROS; Nature, 475 7355
2) Adams et al. (2012), Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs; Proc. Natl. Acad. Sci. USA, 109 15115
3) Jarvius et al. (2013), Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells; Biochem. Biophys. Res. Commun. 431 117
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Piperlongumine (20069-09-4) elevates cellular levels of reactive oxygen species selectively in cancer cell lines.1 Irreversible glutathionylation leading to depletion of cellular glutathione is associated with its cellular toxicity.2 Piperlongumine does not appear to have any effect on normal cells. Displays anti-tumor effects in a mouse xenograft tumor model as well as in spontaneously formed malignant breast tumors in mice.1 Elevation of ROS levels in response to piperlongumine may be due to inhibition of ubiquitin-proteasome system at a pre-proteasomal step.3
References/Citations:
1) Raj et al. (2011), Selective killing of cancer cells by a small molecule targeting the stress response to ROS; Nature, 475 7355
2) Adams et al. (2012), Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs; Proc. Natl. Acad. Sci. USA, 109 15115
3) Jarvius et al. (2013), Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells; Biochem. Biophys. Res. Commun. 431 117
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