PIT-1 | PH domain antagonist
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $35.00 | ||
| 50 mg | $120.00 |
PIT-1 (53501-41-0) is a PH domain antagonist. Specifically blocks the binding of PIP3 to the Akt pleckstrin homology domain (IC50 = 31 mM). Suppresses PI3K-PDK1-Akt-dependent phosphorylation. Induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 mM).1 Inhibiting the binding of PIP3 to effector PH domains is new point of intervention in the PI3K signaling network.2
References/Citations:
1) Maio et al. (2010), Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PI3) binding to pleckstrin homology domains; Proc. Natl. Acad. Sci. USA, 107 20126
2) McNamare and Degterev (2011), Small-molecule inhibitor of the PI3K signaling network; Future Med. Chem., 3 549
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
PIT-1 (53501-41-0) is a PH domain antagonist. Specifically blocks the binding of PIP3 to the Akt pleckstrin homology domain (IC50 = 31 mM). Suppresses PI3K-PDK1-Akt-dependent phosphorylation. Induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 mM).1 Inhibiting the binding of PIP3 to effector PH domains is new point of intervention in the PI3K signaling network.2
References/Citations:
1) Maio et al. (2010), Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PI3) binding to pleckstrin homology domains; Proc. Natl. Acad. Sci. USA, 107 20126
2) McNamare and Degterev (2011), Small-molecule inhibitor of the PI3K signaling network; Future Med. Chem., 3 549
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