Size : | Price | Quantity | |
---|---|---|---|
10 mg | $35.00 | ||
50 mg | $120.00 |
PIT-1 (53501-41-0) is a PH domain antagonist. Specifically blocks the binding of PIP3 to the Akt pleckstrin homology domain (IC50 = 31 mM). Suppresses PI3K-PDK1-Akt-dependent phosphorylation. Induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 mM).1 Inhibiting the binding of PIP3 to effector PH domains is new point of intervention in the PI3K signaling network.2
References/Citations:
1) Maio et al. (2010), Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PI3) binding to pleckstrin homology domains; Proc. Natl. Acad. Sci. USA, 107 20126
2) McNamare and Degterev (2011), Small-molecule inhibitor of the PI3K signaling network; Future Med. Chem., 3 549
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PIT-1 (53501-41-0) is a PH domain antagonist. Specifically blocks the binding of PIP3 to the Akt pleckstrin homology domain (IC50 = 31 mM). Suppresses PI3K-PDK1-Akt-dependent phosphorylation. Induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 mM).1 Inhibiting the binding of PIP3 to effector PH domains is new point of intervention in the PI3K signaling network.2
References/Citations:
1) Maio et al. (2010), Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PI3) binding to pleckstrin homology domains; Proc. Natl. Acad. Sci. USA, 107 20126
2) McNamare and Degterev (2011), Small-molecule inhibitor of the PI3K signaling network; Future Med. Chem., 3 549
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