PIT-1 | PH domain antagonist

CAS:
53501-41-0
Catalog Number:
10-1192
Activity:
PH domain antagonist
Chemical Name:
N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide
Molecular Weight:
351.76
Molecular Formula:
C14H10ClN3O4S
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 3 mg/ml)
Physical Properties:
Grey solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
10 mg$35.00
50 mg$120.00

PIT-1 (53501-41-0) is a PH domain antagonist. Specifically blocks the binding of PIP3 to the Akt pleckstrin homology domain (IC50 = 31 mM). Suppresses PI3K-PDK1-Akt-dependent phosphorylation. Induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 mM).1 Inhibiting the binding of PIP3 to effector PH domains is new point of intervention in the PI3K signaling network.2

References/Citations:

1) Maio et al. (2010), Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PI3) binding to pleckstrin homology domains; Proc. Natl. Acad. Sci. USA, 107 20126
2) McNamare and Degterev (2011), Small-molecule inhibitor of the PI3K signaling network; Future Med. Chem., 3 549

CAS:
53501-41-0
Catalog Number:
10-1192
Activity:
PH domain antagonist
Chemical Name:
N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide
Molecular Weight:
351.76
Molecular Formula:
C14H10ClN3O4S
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 3 mg/ml)
Physical Properties:
Grey solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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