PKSI-527 | Selective plasma kallikrein inhibitor
CAS:
128837-71-8
Catalog Number:
10-2220
Activity:
Selective plasma kallikrein inhibitor
Chemical Names:
trans-4-Aminomethylcyclohexanecarbonyl-phenylalanyl-4-carboxymethylanilide
Molecular Weight:
474.01
Molecular Formula:
C25H31N3O4·HCl
Solubility:
Soluble in Water (5 mg/ml)
Physical Properties:
White solid
Purity:
97% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $75.00 | ||
| 25 mg | $300.00 |
PKSI-527 (128837-71-8) is a selective plasma kallikrein inhibitor (Ki = 0.81 µM)1 that can be used for affinity purification of kallikrein2. Synergizes with NO donors to produce antithrombic effects ex-vivo.3 Suppresses collagen-induced arthritis in mouse models.4
References:
- Wanaka et al. (1992), Synthesis of trans-4-aminomethylcyclohexanecarbonyl-L- and –D-phenylalanine-4-carboxymethylanilide and examination of their inhibitory activity against plasma kallikrein; Chem. Pharm. Bull., 40 1814
- Tada et al. (2001), Isolation of plasma kallikrein by high efficiency affinity chromatography and its characterization; Chem. Pharm. Bull., 24 520
- Ikarugi et al. (2005), Synergistic antithrombotic effect of a combination of NO donor and plasma kallikrein inhibitor; Thromb. Res., 116 403
- Fujimori et al. (1993), Effects of a highly selective plasma kallikrein inhibitor on collagen-induced arthritis in mice; Agents Actions, 39 42
CAS:
128837-71-8
Catalog Number:
10-2220
Activity:
Selective plasma kallikrein inhibitor
Chemical Names:
trans-4-Aminomethylcyclohexanecarbonyl-phenylalanyl-4-carboxymethylanilide
Molecular Weight:
474.01
Molecular Formula:
C25H31N3O4·HCl
Solubility:
Soluble in Water (5 mg/ml)
Physical Properties:
White solid
Purity:
97% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
PKSI-527 (128837-71-8) is a selective plasma kallikrein inhibitor (Ki = 0.81 µM)1 that can be used for affinity purification of kallikrein2. Synergizes with NO donors to produce antithrombic effects ex-vivo.3 Suppresses collagen-induced arthritis in mouse models.4
References:
- Wanaka et al. (1992), Synthesis of trans-4-aminomethylcyclohexanecarbonyl-L- and –D-phenylalanine-4-carboxymethylanilide and examination of their inhibitory activity against plasma kallikrein; Chem. Pharm. Bull., 40 1814
- Tada et al. (2001), Isolation of plasma kallikrein by high efficiency affinity chromatography and its characterization; Chem. Pharm. Bull., 24 520
- Ikarugi et al. (2005), Synergistic antithrombotic effect of a combination of NO donor and plasma kallikrein inhibitor; Thromb. Res., 116 403
- Fujimori et al. (1993), Effects of a highly selective plasma kallikrein inhibitor on collagen-induced arthritis in mice; Agents Actions, 39 42
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