PNF1 | Angiogenesis inducer
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $70.00 | ||
| 25 mg | $280.00 |
PNF1 (10442-95-2) is a novel small molecule inducer of angiogenesis which has been shown to be useful in tissue engineering applications.1 In a sustained release model, PNF1 promoted ingrowth and expansion of microvascular networks surrounding biomaterial implants.2 Its mechanism of action includes induction of TNF-α followed by TGF-β signaling and subsequent modulation of MMP14 (MT1-MMP) in human microvascular endothelial cells.3,4
References/Citations:
- Wieghaus et al. (2006) Small molecule inducers of angiogenesis for tissue engineering; Tissue Eng. 12 1903
- Wieghaus et al. (2008) Expansion of microvascular networks in vivo by phthalimide neovascular factor 1 (PNF1); Biomaterials 29 4698
- Wieghaus et al. (2008) Novel pathway compendium analysis elucidates mechanism of pro-angiogenic synthetic small molecule; Bioinformatics 24 2384
- Wieghaus et al. (2009) Phthalimide neovascular factor 1 (PNF1) modulates MT1-MMP activity in human microvascular endothelial cells; Biotechnol. Bioeng. 103 796
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
PNF1 (10442-95-2) is a novel small molecule inducer of angiogenesis which has been shown to be useful in tissue engineering applications.1 In a sustained release model, PNF1 promoted ingrowth and expansion of microvascular networks surrounding biomaterial implants.2 Its mechanism of action includes induction of TNF-α followed by TGF-β signaling and subsequent modulation of MMP14 (MT1-MMP) in human microvascular endothelial cells.3,4
References/Citations:
- Wieghaus et al. (2006) Small molecule inducers of angiogenesis for tissue engineering; Tissue Eng. 12 1903
- Wieghaus et al. (2008) Expansion of microvascular networks in vivo by phthalimide neovascular factor 1 (PNF1); Biomaterials 29 4698
- Wieghaus et al. (2008) Novel pathway compendium analysis elucidates mechanism of pro-angiogenic synthetic small molecule; Bioinformatics 24 2384
- Wieghaus et al. (2009) Phthalimide neovascular factor 1 (PNF1) modulates MT1-MMP activity in human microvascular endothelial cells; Biotechnol. Bioeng. 103 796
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