Polygodial | TRPA1 activator
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $220.00 |
Polygodial (6754-20-7) is a TRPA1 activator (EC50=400 nM).1 A naturally occurring drimane sesquiterpene dialdehyde found in a variety of plant species including water pepper (Polygonum hydropiper). Polygodial has been used in folk medicine for a variety of indications. Displays analgesic activity via desensitization of sensory neurons.2
References/Citations:
1) Escalera et al. (2008), TRPA1 mediates the noxious effects of natural sesquiterpene deterrents; J. Biol. Chem., 283 24136
2) Andre et al. (2004), Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdehydes unsaturated sesquiterpenes polygodial and drimanial in rats; Neuropharmacology, 46 590
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Polygodial (6754-20-7) is a TRPA1 activator (EC50=400 nM).1 A naturally occurring drimane sesquiterpene dialdehyde found in a variety of plant species including water pepper (Polygonum hydropiper). Polygodial has been used in folk medicine for a variety of indications. Displays analgesic activity via desensitization of sensory neurons.2
References/Citations:
1) Escalera et al. (2008), TRPA1 mediates the noxious effects of natural sesquiterpene deterrents; J. Biol. Chem., 283 24136
2) Andre et al. (2004), Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdehydes unsaturated sesquiterpenes polygodial and drimanial in rats; Neuropharmacology, 46 590
Related products
-
Dofetilide | hERG channel blocker
From $65.00CAS:115256-11-6Catalog Number:10-1151Activity:hERG channel blockerAlternate Names:TikosynChemical Name:N-[4-(2-{[2-(4-Methanesulfonamidophenoxy)ethyl](methyl)amino}ethyl)phenyl]methanesulfonamideMolecular Weight:441.56Molecular Formula:C19H27N3O5S2Solubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
AP-18 | TRPA1 blocker
From $70.00CAS:55224-94-7Catalog Number:10-1127Activity:TRPA1 blockerChemical Name:4-(4-Chlorophenyl)-3-methylbut-3-en-2-oximeMolecular Weight:209.67Molecular Formula:C11H12ClNOSolubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.Shipping Code:RT -
SKF-96365 | TRPC channel blocker
From $65.00CAS:130495-35-1Catalog Number:10-1068Activity:TRPC channel blockerChemical Name:1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole hydrochlorideMolecular Weight:402.92Molecular Formula:C22H26N2O3 HClSolubility:Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
