Ponasterone A | Insect steroid hormone
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 1 mg | $50.00 | ||
| 5 mg | $200.00 |
Ponasterone A (13408-56-5) is a potent ecdysone agonist which elicits molting and metamorphosis in insects.1 Ponasterone A and related ecdysteroids have been used as activators in ecdysone-inducible mammalian expression systems.2,3 Has been used to create an inducible cell model for Huntingdon’s disease.4 Ecdysone analogs have been shown to display a strong antiapoptotic effect in mammalian cell lines thus ecdysone-based expression systems may not be suitable for analysis of apoptosis-related genes.5
References/Citations:
- Gonsalves et al. (2011), Genome-wide examination of the transcriptional response to ecdysteroids 20-hydroxyecdysone and ponasterone A in Drosophila melanogaster; BMC Genomics 12 475
- Lafont and Dinan (2003), Practical uses for ecdysterones in mammals including humans: an update; J. Insect Sci. 3 7
- Saez et al. (2000), Identification of ligands and coligands for the ecdysone-regulated gene switch; Proc Nat. Acad. Sci USA 97 14512
- Chen et al. (2018), Heat shock promotes inclusion body formation of mutant huntingtin (mHtt) and alleviates mHtt-induced transcription factor dysfunction; J. Biol. Sci. 293 15581
- Oehme et al. (2006), Agonists of an ecdysone-inducible mammalian expression system inhibit Fas Ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO; Cell Death Differ. 13 189
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Ponasterone A (13408-56-5) is a potent ecdysone agonist which elicits molting and metamorphosis in insects.1 Ponasterone A and related ecdysteroids have been used as activators in ecdysone-inducible mammalian expression systems.2,3 Has been used to create an inducible cell model for Huntingdon’s disease.4 Ecdysone analogs have been shown to display a strong antiapoptotic effect in mammalian cell lines thus ecdysone-based expression systems may not be suitable for analysis of apoptosis-related genes.5
References/Citations:
- Gonsalves et al. (2011), Genome-wide examination of the transcriptional response to ecdysteroids 20-hydroxyecdysone and ponasterone A in Drosophila melanogaster; BMC Genomics 12 475
- Lafont and Dinan (2003), Practical uses for ecdysterones in mammals including humans: an update; J. Insect Sci. 3 7
- Saez et al. (2000), Identification of ligands and coligands for the ecdysone-regulated gene switch; Proc Nat. Acad. Sci USA 97 14512
- Chen et al. (2018), Heat shock promotes inclusion body formation of mutant huntingtin (mHtt) and alleviates mHtt-induced transcription factor dysfunction; J. Biol. Sci. 293 15581
- Oehme et al. (2006), Agonists of an ecdysone-inducible mammalian expression system inhibit Fas Ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO; Cell Death Differ. 13 189
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