PP2 | Src family kinase inhibitor
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $165.00 |
PP2 (172889-27-9) is a potent and selective Src family kinase inhibitor. Inhibits Lck(IC50=4 nM); Fyn (IC50=5 nM); Hck (IC50=5 nM). It displays weak inhibition of EGFR (IC50=480 nM) and no inhibition of ZAP-70 (IC50> 100 μM) and JAK2 (IC50> 50 μM).1 PP2 is a useful probe for exploring the involvement of Src family kinases in signal transduction pathways.2
References/Citations:
1) Hanke et al. (1996), Discovery of a novel, potent and Src family-selective kinase inhibitor. Study of Lck-and FynT-dependent T cell activation; J. Biol. Chem., 271 695
2) Yoshizume et al. (2000), Src and Cas mediate JNK activation but not ERK1/2 and p38 kinases by reactive oxygen species; J. Biol. Chem., 275 11706
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
PP2 (172889-27-9) is a potent and selective Src family kinase inhibitor. Inhibits Lck(IC50=4 nM); Fyn (IC50=5 nM); Hck (IC50=5 nM). It displays weak inhibition of EGFR (IC50=480 nM) and no inhibition of ZAP-70 (IC50> 100 μM) and JAK2 (IC50> 50 μM).1 PP2 is a useful probe for exploring the involvement of Src family kinases in signal transduction pathways.2
References/Citations:
1) Hanke et al. (1996), Discovery of a novel, potent and Src family-selective kinase inhibitor. Study of Lck-and FynT-dependent T cell activation; J. Biol. Chem., 271 695
2) Yoshizume et al. (2000), Src and Cas mediate JNK activation but not ERK1/2 and p38 kinases by reactive oxygen species; J. Biol. Chem., 275 11706
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