Pranlukast | Leukotriene CysLT1 antagonist / GPR17 antagonist

CAS:
103177-37-3
Catalog Number:
10-2441
Activity:
Leukotriene CysLT1 antagonist / GRP17 antagonist
Chemical Name:
N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzami
Alternate Names:
ONO-1078
Molecular Weight:
481.51
Molecular Formula:
C27H23N5O4
Solubility:
Soluble in DMSO (up to 25 mg/ml)
Physical Properties:
White solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
50 mg$50.00
250 mg$195.00

Pranlukast (103177-37-3)is a selective Leukotriene CysLT1 antagonist1 and has been used in the treatment of asthma2. Pranlukast is also an inhibitor of GPR173 (IC50’s = 10.5nM hGPR17, 31nM rGPR17) and is superior to Montelukast in achieving functional inhibition4.

References/Citations:

1) Nakai et al. (1988), New Potent Antagonists of Leukotrienes C4 and D4. 1. Synthesis and Structure-Activity Relationships; J. Med. Chem. 31 84
2) Taniguchi et al. (1993), The effect of an oral leukotriene antagonist, ONO-1078, on allergen-induced immediate bronchoconstriction in asthmatic subjects; J. Allergy Clin. Immunol. 92 507
3) Ciana et al. (2006), The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor; EMBO J. 25 4615
4) Hennen et al. (2013), Decoding Signaling and Function of the Orphan G Protein-Coupled Receptor GPR17 with a Small-Molecule Agonist; Sci. Signal. 6 ra93

CAS:
103177-37-3
Catalog Number:
10-2441
Activity:
Leukotriene CysLT1 antagonist / GRP17 antagonist
Chemical Name:
N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzami
Alternate Names:
ONO-1078
Molecular Weight:
481.51
Molecular Formula:
C27H23N5O4
Solubility:
Soluble in DMSO (up to 25 mg/ml)
Physical Properties:
White solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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