Pranlukast | Leukotriene CysLT1 antagonist / GPR17 antagonist
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 50 mg | $50.00 | ||
| 250 mg | $195.00 |
Pranlukast (103177-37-3)is a selective Leukotriene CysLT1 antagonist1 and has been used in the treatment of asthma2. Pranlukast is also an inhibitor of GPR173 (IC50’s = 10.5nM hGPR17, 31nM rGPR17) and is superior to Montelukast in achieving functional inhibition4.
References/Citations:
1) Nakai et al. (1988), New Potent Antagonists of Leukotrienes C4 and D4. 1. Synthesis and Structure-Activity Relationships; J. Med. Chem. 31 84
2) Taniguchi et al. (1993), The effect of an oral leukotriene antagonist, ONO-1078, on allergen-induced immediate bronchoconstriction in asthmatic subjects; J. Allergy Clin. Immunol. 92 507
3) Ciana et al. (2006), The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor; EMBO J. 25 4615
4) Hennen et al. (2013), Decoding Signaling and Function of the Orphan G Protein-Coupled Receptor GPR17 with a Small-Molecule Agonist; Sci. Signal. 6 ra93
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Pranlukast (103177-37-3)is a selective Leukotriene CysLT1 antagonist1 and has been used in the treatment of asthma2. Pranlukast is also an inhibitor of GPR173 (IC50’s = 10.5nM hGPR17, 31nM rGPR17) and is superior to Montelukast in achieving functional inhibition4.
References/Citations:
1) Nakai et al. (1988), New Potent Antagonists of Leukotrienes C4 and D4. 1. Synthesis and Structure-Activity Relationships; J. Med. Chem. 31 84
2) Taniguchi et al. (1993), The effect of an oral leukotriene antagonist, ONO-1078, on allergen-induced immediate bronchoconstriction in asthmatic subjects; J. Allergy Clin. Immunol. 92 507
3) Ciana et al. (2006), The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor; EMBO J. 25 4615
4) Hennen et al. (2013), Decoding Signaling and Function of the Orphan G Protein-Coupled Receptor GPR17 with a Small-Molecule Agonist; Sci. Signal. 6 ra93
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