PRE084 | Selective sigma-1 agonist
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $175.00 |
PRE084 (138847-85-5) is an agonist of the σ receptor with selectivity for the σ1 subtype (IC50’s: σ1 = 2.2nM, σ2 = 13091nM).1 PRE-084 has demonstrated neuroprotective/restorative effects in brain injury2,3 and neurodegenerative conditions4-7.
References/Citations:
1) Su et al. (1991), Sigma compounds derived from phencyclidine. Identification of PRE-084, a new selective sigma ligand; J. Pharmacol. Exp. Ther. 259 543
2) Griesmaier et al. (2012), Neuroprotective effects of the sigma-1 receptor ligand PRE-084 against excitotoxic perinatal brain injury in newborn mice; Exp. Neurol. 237 388
3) Dong et al. (2016), Sigma-1 Receptor Modulates Neuroinflammation After Traumatic Brain Injury; Cell Mol. Neurobiol. 36 639
4) Guzman-Lenis et al. (2009), Selective sigma receptor agonist 2-(4-Morpholinethyl) 1-phenylcyclohexanecarboxylate (PRE084) promotes neuroprotection and neurite elongation through protein kinase C (PKC) signaling on motoneurons; Neuroscience 162 31
5) Hyrskyluoto et al. (2013), Sigma-1 receptor agonist PRE084 in protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-κB pathway; Cell Death Dis. 4 e646
6) Francardo et al. (2014), Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism; Brain 137(Pt7) 1998
7) Mancuso et al. (2012), Sigma-1R agonist improves motor function and motoneuron survival in ALS mice; Neurotherapeutics 9 814
NMR (Conforms)
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Product Data Sheet:
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PRE084 (138847-85-5) is an agonist of the σ receptor with selectivity for the σ1 subtype (IC50’s: σ1 = 2.2nM, σ2 = 13091nM).1 PRE-084 has demonstrated neuroprotective/restorative effects in brain injury2,3 and neurodegenerative conditions4-7.
References/Citations:
1) Su et al. (1991), Sigma compounds derived from phencyclidine. Identification of PRE-084, a new selective sigma ligand; J. Pharmacol. Exp. Ther. 259 543
2) Griesmaier et al. (2012), Neuroprotective effects of the sigma-1 receptor ligand PRE-084 against excitotoxic perinatal brain injury in newborn mice; Exp. Neurol. 237 388
3) Dong et al. (2016), Sigma-1 Receptor Modulates Neuroinflammation After Traumatic Brain Injury; Cell Mol. Neurobiol. 36 639
4) Guzman-Lenis et al. (2009), Selective sigma receptor agonist 2-(4-Morpholinethyl) 1-phenylcyclohexanecarboxylate (PRE084) promotes neuroprotection and neurite elongation through protein kinase C (PKC) signaling on motoneurons; Neuroscience 162 31
5) Hyrskyluoto et al. (2013), Sigma-1 receptor agonist PRE084 in protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-κB pathway; Cell Death Dis. 4 e646
6) Francardo et al. (2014), Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism; Brain 137(Pt7) 1998
7) Mancuso et al. (2012), Sigma-1R agonist improves motor function and motoneuron survival in ALS mice; Neurotherapeutics 9 814
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