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Pridopidine | Sigma-1 ligand Neuroprotectant/Neurorestorative

Pridopidine is being studied as a potential treatment for Huntington’s disease, Parkinson’s disease, and schizophrenia based on its locomotor stabilizing and antipsychotic-like effects.1,2 It was, unusually, able to reverse both hypo- and hyperdopaminergia depending on local dopamine concentrations without inducing catalepsy. This was originally attributed to functional dopamine D2 antagonism with fast on/off kinetics (“dopamine stabilizer”).3 More recent studies have attributed Pridopidines effects to its being a more potent Sigma-1 ligand than a D2 ligand.4,5 Displays neuroprotective/restorative effects6,7 and ameliorates central features of Amyotrophic Lateral Sclerosis pathology8 in a sigma-1-mediated manner

1) Pettersson (2010), Synthesis and Evaluation of a Set of 4-Phenylpiperidines and 4-Phenylpiperazines as D2 Receptor Ligands and the Discovery of the Dopaminergic Stabilizer 4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine (Huntexil, Pridopidine, ACR16); J.Med.Chem. 53 2510
2) The dopamine stabilizers (S)-(-)-(3-methanesulfonylphenyl)-1-propyl-piperidine [(-)-OSU6162] and 4-(3-methanesulfonylphenyl)-1-propyl-piperidine (ACR16) show high in vivo D2 receptor occupancy, antipsychotic-like efficacy, and low potential for motor side effects in the rat; J.Pharmacol.Exp.Ther. 318 810
3) Dyhring et al. (2010) The dopaminergic stabilizers pridopidine (ACR16) and (-)-OSU6162 display dopamine D(2) receptor antagonism and fast receptor dissociation properties; Eur.J.Pharmacol. 628 19
4) Sahlholm (2015) Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses; Psychopharmacology (Berl) 232 3443
Sahlholm et al. (2013), The dopamine stabilizers ACR16 and (-)-OSU6162 display nanomolar affinities at the s-1 receptor; Mol.Psychiatry 18 12
6) Francardo et al. (2019), Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson’s Disease; Neurotherapeutics epub ahead of print
7) Ryskamp, et al. (2017), The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease; Neurobiol.Dis. 97(Pt A) 46
8) Ionescu et al. (2019), Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1G93A Model; Cell Death Dis. 10 210

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Catalog#  10-4003-005

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Catalog Number:
Sigma-1 ligand Neuroprotectant Neurorestorative
Chemical Name:
Alternate Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
White solid
>98% by TLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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