Neurodegeneration

Neurodegeneration is a progressive deterioration of neuronal structures and function that ultimately leads to cognitive disability, dementia, and/or motor defects depending on the affected area of the brain. Neurodegenerative disorders can be caused by genetic mutations, aggregation of misfolded proteins, accumulation of toxic intracellular proteins, organelle membrane damage, and mitochondrial dysfunction. Common disorders include multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease.

ALS

  • Violacein | Immunostimulant
    CAS:
    548-54-9
    Catalog Number:
    10-5073
  • Crisdesalazine | PGE2 synthase inhibitor
    CAS:
    927685-43-6
    Catalog Number:
    10-4416
  • Repaglinide | Kir6 blocker
    CAS:
    135062-02-1
    Catalog Number:
    10-4661
  • Pridopidine | Sigma-1 ligand Neuroprotectant/Neurorestorative
    CAS:
    346688-38-8
    Catalog Number:
    10-4003
    Activity:
    Sigma-1 ligand Neuroprotectant Neurorestorative
    Chemical Name:
    4-(3-(Methylsulfonyl)phenyl)-1-propylpiperidine
    Alternate Name:
    ACR16
    Molecular Weight:
    281.41
    Molecular Formula:
    C15H23NO2S
    Solubility:
    Soluble in DMSO (up to 10 mg/ml).
    Physical Properties:
    White solid
    Purity:
    >98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Riluzole | Sodium channel blocker / Neuroprotective
    CAS:
    1744-22-5
    Catalog Number:
    10-2815
    Activity:
    Sodium channel blocker / Neuroprotective
    Chemical Name:
    2-Amino-6-(trifluoromethoxy)benzothiazole
    Molecular Weight:
    234.20
    Molecular Formula:
    C8H5F3N2OS
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All ALS Products

Alzheimers

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Huntingtons

  • PF-04447943 | Selective PDE9A inhibitor
    CAS:
    1082744-20-4
    Catalog Number:
    10-4365
  • Repaglinide | Kir6 blocker
    CAS:
    135062-02-1
    Catalog Number:
    10-4661
  • Laquinimod | Immunomodulator
    CAS:
    248281-84-7
    Catalog Number:
    10-4971
    Activity:
    Immunomodulator
    Chemical Names:
    5-Chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenylquinoline-3-carboxamide
    Alternate Name:
    ABR-215062
    Molecular Weight:
    356.81
    Molecular Formula:
    C19H17ClN2O3
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • QNZ | NFkB inhibitor / Store operated calcium entry
    CAS:
    545380-34-5
    Catalog Number:
    10-4009
    Activity:
    NF-kB inhibitor / Store-operated calcium entry
    Chemical Name:
    4-N-[2-(4-Phenoxyphenyl)ethyl]quinazoline-4,6-diamine
    Alternate Name:
    EVP4593
    Molecular Weight:
    356.42
    Molecular Formula:
    C22H20N4O
    Solubility:
    Soluble in DMSO (up to 20 mg/ml).
    Physical Properties:
    Pale yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Pridopidine | Sigma-1 ligand Neuroprotectant/Neurorestorative
    CAS:
    346688-38-8
    Catalog Number:
    10-4003
    Activity:
    Sigma-1 ligand Neuroprotectant Neurorestorative
    Chemical Name:
    4-(3-(Methylsulfonyl)phenyl)-1-propylpiperidine
    Alternate Name:
    ACR16
    Molecular Weight:
    281.41
    Molecular Formula:
    C15H23NO2S
    Solubility:
    Soluble in DMSO (up to 10 mg/ml).
    Physical Properties:
    White solid
    Purity:
    >98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Huntingtons Products

Multiple sclerosis

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Neuronal stem cells

  • Guggulsterone-(Z) | FXR antagonist
    CAS:
    39025-23-5
    Catalog Number:
    10-3816
    Activity:
    FXR antagonist
    Chemical Name:
    (Z)-Pregna-4,17(20)-diene-3,16-dione
    Molecular Weight:
    312.45
    Molecular Formula:
    C21H28O2
    Solubility:
    Soluble in DMSO (up to 6 mg/ml with warming) or in Ethanol (up to 3 mg/ml with warming).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Neurodazine | Induces stem cell neuronal differentiation
    CAS:
    937807-66-4
    Catalog Number:
    10-4515
    Activity:
    Induces stem cell neuronal differentiation
    Chemical Name:
    2-[5-(3-Chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole
    Molecular Weight:
    456.92
    Molecular Formula:
    C27H21ClN2O3
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    Beige solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • TOFA | Acyl-CoA carboxylase inhibitor
    CAS:
    54857-86-2
    Catalog Number:
    10-1464
    Activity:
    Acyl-CoA carboxylase inhibitor
    Alternate Names:
    RMI-14514
    Chemical Name:
    5-(Tetradecyloxy)-2-furoic acid
    Molecular Weight:
    324.47
    Molecular Formula:
    C19H32O4
    Solubility:
    Soluble in DMSO (up to 15 mg/ml), or in Ethanol (up to 9 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • ISX9 | Neurogenic differentiation inducer
    CAS:
    832115-62-5
    Catalog Number:
    10-1357
    Activity:
    Neurogenic differentiation inducer
    Chemical Name:
    N-Cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamide
    Molecular Weight:
    234.28
    Molecular Formula:
    C11H10N2O2S
    Solubility:
    Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 16 mg/ml).
    Physical Properties:
    Tan solid
    Purity:
    99% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Neuropathiazol | Induces neuronal differentiation
    CAS:
    880090-88-0
    Catalog Number:
    10-1291
    Activity:
    Induces neuronal differentiation
    Chemical Name:
    Ethyl 4-(methyl(2-phenylthiazol-4-yl)amino)benzoate
    Molecular Weight:
    338.43
    Molecular Formula:
    C19H18N2O2S
    Solubility:
    Soluble in DMSO (up to 10 mg/ml).
    Physical Properties:
    Off white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
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Other Neurodegeneration

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Parkinsons

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