Pritelivir | HSV helicase-primase inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $50.00 | ||
| 50 mg | $150.00 |
Pritelivir (348086-71-5) is a potent non-nucleosidic inhibitor of the herpes simplex virus helicase-primase (IC50 = 20 nM HSV1/2).1 Active against acyclovir-resistant HSV. Pritelivir showed superior efficacy against HSV in vivo compared to acyclovir, famiciclovir, ganciclovir, and valacyclovir.2 It greatly reduced the formation of ß-amyloid and abnormal tau in HSV1 infected cultured cells.3
References/Citations:
- Kleyman et al. (2002), New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease; Nat. Med. 8 392
- Betz et al. (2002), Potent In Vivo Activity of the Herpes Simplex Virus Primase-Helicase Inhibitor BAY 57-1293; Antimicrob. Agents Chemother. 46 1766
- Wozniak et al. (2013), The helicase-primase inhibitor BAY 57-1293 reduces the Alzheimer’s disease-related molecules induced by herpes simplex virus type 1; Antiviral Res. 99 401
C18H18N4O3S2
>98% HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Pritelivir (348086-71-5) is a potent non-nucleosidic inhibitor of the herpes simplex virus helicase-primase (IC50 = 20 nM HSV1/2).1 Active against acyclovir-resistant HSV. Pritelivir showed superior efficacy against HSV in vivo compared to acyclovir, famiciclovir, ganciclovir, and valacyclovir.2 It greatly reduced the formation of ß-amyloid and abnormal tau in HSV1 infected cultured cells.3
References/Citations:
- Kleyman et al. (2002), New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease; Nat. Med. 8 392
- Betz et al. (2002), Potent In Vivo Activity of the Herpes Simplex Virus Primase-Helicase Inhibitor BAY 57-1293; Antimicrob. Agents Chemother. 46 1766
- Wozniak et al. (2013), The helicase-primase inhibitor BAY 57-1293 reduces the Alzheimer’s disease-related molecules induced by herpes simplex virus type 1; Antiviral Res. 99 401
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
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