Probucol | Antioxidant hypercholesterolemic agent
Available Options
| Size | Price | Quantity | |
|---|---|---|---|
| 1g | $48.00 | ||
| 10g | $100.00 |
Probucol (23288-49-5) is a unique antilipidemic drug which inhibits the oxidation of LDL cholesterol preventing the genesis of macrophage-derived foam cells and thus suppressing the formation of atherosclerotic vascular lesions.1 It inhibits ABCA1-mediated cholesterol efflux without influencing scavenger receptor (class B type 1)-mediated efflux.2 It enhances mitophagy and improves survival, locomotor function and dopaminergic neuron loss in zebrafish and fly models of mitochondrial damage.3 It attenuates NF-kB/NLRP3 signaling and augments Nrf-2-mediated antioxidant defense in nerve injury models.4 Improves learning and memory in aging mice.5 It protects neuronal cells against peroxide-induced damage and directly activates glutathione peroxidase-1.6
References/Citations:
- Yamamoto et al. (2013), A unique antilipidemic drug – Probucol; J. Atheroscler. Thromb. 15 304
- Favari et al. (2004), Probucol inhibits ABCA1-mediated cellular lipid efflux; Arterioscler. Thromb. Vasc. Biol. 24 2345
- Moskal et al. (2023), An AI-guided screen identifies probucol as an enhancer of mitophagy through modulation of lipid droplets; PLoS Biol. 21 e3001977
- Derangula et al. (2022), Probucol attenuates NF-kB/NLRP3 signaling and augments Nrf-1 mediated antioxidant defence in nerve injury induced neuropathic pain; Immunopharmacol 102 108397
- Xie et al. (2021), Effects and mechanisms of probucol on aging-related hippocampus-dependent cognitive impairment; Biomed. Pharmacother. 144 112266
- Santos et al. (2020), Probucol Protects Neuronal Cells Against Peroxide-Induced Damage and Directly Activates Glutathione Peroxidase-1; Mol. Neurobiol. 57 3245
C31H48O2S2
>98% HPLC
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Probucol (23288-49-5) is a unique antilipidemic drug which inhibits the oxidation of LDL cholesterol preventing the genesis of macrophage-derived foam cells and thus suppressing the formation of atherosclerotic vascular lesions.1 It inhibits ABCA1-mediated cholesterol efflux without influencing scavenger receptor (class B type 1)-mediated efflux.2 It enhances mitophagy and improves survival, locomotor function and dopaminergic neuron loss in zebrafish and fly models of mitochondrial damage.3 It attenuates NF-kB/NLRP3 signaling and augments Nrf-2-mediated antioxidant defense in nerve injury models.4 Improves learning and memory in aging mice.5 It protects neuronal cells against peroxide-induced damage and directly activates glutathione peroxidase-1.6
References/Citations:
- Yamamoto et al. (2013), A unique antilipidemic drug – Probucol; J. Atheroscler. Thromb. 15 304
- Favari et al. (2004), Probucol inhibits ABCA1-mediated cellular lipid efflux; Arterioscler. Thromb. Vasc. Biol. 24 2345
- Moskal et al. (2023), An AI-guided screen identifies probucol as an enhancer of mitophagy through modulation of lipid droplets; PLoS Biol. 21 e3001977
- Derangula et al. (2022), Probucol attenuates NF-kB/NLRP3 signaling and augments Nrf-1 mediated antioxidant defence in nerve injury induced neuropathic pain; Immunopharmacol 102 108397
- Xie et al. (2021), Effects and mechanisms of probucol on aging-related hippocampus-dependent cognitive impairment; Biomed. Pharmacother. 144 112266
- Santos et al. (2020), Probucol Protects Neuronal Cells Against Peroxide-Induced Damage and Directly Activates Glutathione Peroxidase-1; Mol. Neurobiol. 57 3245
Related products
-
TCEP HCl | Reducing agent
From $35.00CAS:51805-45-9Catalog Number:10-2961Activity:Reducing agentChemical Name:Tris(-Carboxyethyl)phosphine HClMolecular Weight:286.65Molecular Formula:C9H15O6P • HClSolubility:Soluble in Water (up to 50 mg/ml)Physical Properties:White solidPurity:99% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.Shipping Code:RT -
Norfluoxetine HCl | Fluoxetine Metabolite
From $60.00CAS:57226-68-3Catalog Number:10-2671Alternate Name:DesmethylfluoxetineActivity:Fluoxetine metaboliteChemical Name:3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamine hydrochloride (racemic)Molecular Weight:331.76Molecular Formula:C16H16F3NO HClSolubility:Soluble in DMSO ( up to at least 25 mg/ml)Physical Properties:Beige waxy solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
BI 2536 | Dual Plk/BRD4 inhibitor – Destabilizes Myc
From $75.00CAS:755038-02-9Catalog Number:10-4121Activity:Dual Plk/BRD4 inhibitor – Destabilizes MycChemical Name:4-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamideMolecular Weight:521.67Molecular Formula:C28H39N7O3Solubility:Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 25 mg/ml)Physical Properties:Off-white solidPurity:97% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
