Prochlorperazine maleate | Endocytosis inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 100 mg | $55.00 | ||
| 500 mg | $180.00 |
Prochlorperazine maleate (84-02-6) inhibits dynamin and clathrin-mediated endocytosis (CME) with an IC50=5.8 µM for CME.1 Increases tumor cell antigen presentation enhancing the efficacy of anti-tumor mAbs.2 A clinically useful antipsychotic agent3 with antimigraine4 and antiemetic activity5.
References/Citations
1) Daniel et al. (2015), Phenothiazine-derived antipsychotic drugs inhibit dynamin and clathrin-mediated endocytosis; Traffic, 16 635
2) Chew et al. (2020), Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies; Cell, 180 895
3) Hollister et al. (1969), Clinical use of psychotherapeutic drugs: current status; Clin. Pharmacol. Ther., 10 170
4) Cook and Newberry (2018), Emergency Department Use of Intravenous Prochlorperazine for Acute Migraine; Adv. Emerg. Nurs. J., 40 148
5) Van den Berg et al. (1996), The prophylactic antiemetic efficacy of prochlorperazine and ondansetron in nasal septal surgery: a randomized double-blind comparison; Anaesth. Intensive Care, 24 538
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Prochlorperazine maleate (84-02-6) inhibits dynamin and clathrin-mediated endocytosis (CME) with an IC50=5.8 µM for CME.1 Increases tumor cell antigen presentation enhancing the efficacy of anti-tumor mAbs.2 A clinically useful antipsychotic agent3 with antimigraine4 and antiemetic activity5.
References/Citations
1) Daniel et al. (2015), Phenothiazine-derived antipsychotic drugs inhibit dynamin and clathrin-mediated endocytosis; Traffic, 16 635
2) Chew et al. (2020), Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies; Cell, 180 895
3) Hollister et al. (1969), Clinical use of psychotherapeutic drugs: current status; Clin. Pharmacol. Ther., 10 170
4) Cook and Newberry (2018), Emergency Department Use of Intravenous Prochlorperazine for Acute Migraine; Adv. Emerg. Nurs. J., 40 148
5) Van den Berg et al. (1996), The prophylactic antiemetic efficacy of prochlorperazine and ondansetron in nasal septal surgery: a randomized double-blind comparison; Anaesth. Intensive Care, 24 538
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