Cromakalim | ATP-sensitive potassium channel opener
NMR (Conforms)
Available Options
| Size | Price | Quantity | |
|---|---|---|---|
| 5 mg | $48.00 | ||
| 25 mg | $190.00 |
Cromakalim (94470-67-4) is a potent and selective ATP-sensitive potassium channel (KATP or Kir6) opener.1 Dose dependently prevents or suppresses hyperalgesia and allodynia in a sciatic nerve injury model.2 Displays ocular hypotensive and neuroprotective properties.3 Attenuates morphine chronic antinociceptive tolerance.4
References/Citations:
1) Sanguinetti et al. (1988), BRL 34915 (cromakalim) activates ATP-sensitive K+ current in cardiac muscle; Proc. Natl. Acad. Sci. USA, 85 8360
2) Wu et al. (2011), Reopening of ATP-sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cord; Pain, 152 2605
3) Roy Chowdhury et al. (2017), ATP sensitive potassium channel openers: A new class of ocular hypotensive agents; Exp. Eye Res., 158 85
4) Cao et al. (2016), Opening of the Adenosine Triphosphate-sensitive Potassium Channel Attenuates Morphine Tolerance by Inhibiting JNK and Astrocyte Activation in the Spinal Cord; Clin. J. Pain, 32 617
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Cromakalim (94470-67-4) is a potent and selective ATP-sensitive potassium channel (KATP or Kir6) opener.1 Dose dependently prevents or suppresses hyperalgesia and allodynia in a sciatic nerve injury model.2 Displays ocular hypotensive and neuroprotective properties.3 Attenuates morphine chronic antinociceptive tolerance.4
References/Citations:
1) Sanguinetti et al. (1988), BRL 34915 (cromakalim) activates ATP-sensitive K+ current in cardiac muscle; Proc. Natl. Acad. Sci. USA, 85 8360
2) Wu et al. (2011), Reopening of ATP-sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cord; Pain, 152 2605
3) Roy Chowdhury et al. (2017), ATP sensitive potassium channel openers: A new class of ocular hypotensive agents; Exp. Eye Res., 158 85
4) Cao et al. (2016), Opening of the Adenosine Triphosphate-sensitive Potassium Channel Attenuates Morphine Tolerance by Inhibiting JNK and Astrocyte Activation in the Spinal Cord; Clin. J. Pain, 32 617
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