Idebenone | Quinone antioxidant and free radical scavenger
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 20 mg | $70.00 | ||
| 100 mg | $280.00 |
Idebenone (58186-27-9) is an analog of coenzyme Q10 which acts as an antioxidant.1 Protects mitochondrial membranes against lipid peroxidation and blocks glutamate neurotoxicity in vitro and in vivo.2 Increases NGF production with no effect on reactive oxygen species in a cultured rat astrocyte reperfusion injury model.3 Idebenone has been shown to extend lifespan and improves motor function in HtrA2 knockout mice.4
References/Citations:
1) Zs-Nagy (1990) Chemistry, toxicology, pharmacology and pharmacokinetics of idebenone: a review; Gerontol. Geriatr., 11, 177
2) Civenni et al. (1999) Inhibitory effect of the neuroprotective agent idebenone on arachidonic acid metabolism in astrocytes; Eur. .J. Pharmacol., 370 161
3) Takuma et al. (2000) CV-2619 protects cultured astrocytes against reperfusion injury via nerve growth factor production; Eur. J. Pharmacol., 406 333
4) Gerhardt et al. (2011) Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice; PloS One, 6 e28855
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Idebenone (58186-27-9) is an analog of coenzyme Q10 which acts as an antioxidant.1 Protects mitochondrial membranes against lipid peroxidation and blocks glutamate neurotoxicity in vitro and in vivo.2 Increases NGF production with no effect on reactive oxygen species in a cultured rat astrocyte reperfusion injury model.3 Idebenone has been shown to extend lifespan and improves motor function in HtrA2 knockout mice.4
References/Citations:
1) Zs-Nagy (1990) Chemistry, toxicology, pharmacology and pharmacokinetics of idebenone: a review; Gerontol. Geriatr., 11, 177
2) Civenni et al. (1999) Inhibitory effect of the neuroprotective agent idebenone on arachidonic acid metabolism in astrocytes; Eur. .J. Pharmacol., 370 161
3) Takuma et al. (2000) CV-2619 protects cultured astrocytes against reperfusion injury via nerve growth factor production; Eur. J. Pharmacol., 406 333
4) Gerhardt et al. (2011) Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice; PloS One, 6 e28855
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