Cercosporin | ROS-generating fungal toxin
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 1 mg | $60.00 | ||
| 5 mg | $240.00 |
Cercosporin (35082-49-6) is a perylenequinone from the fungus Cercospora kikuchii. Upon photo- activation, perylenequinones display almost universal toxicity to a broad variety of organisms.1 Exposure to visible and near-UV light activates this family of quinones to an excited triplet state that reacts with oxygen to form reactive oxygen species.2 Displays antiproliferative effects in various tumor cell lines.3 Selectively inhibits PKC (IC50=0.6-1.3 µM) over PKA and PPK.4
References/Citations:
- Daub et al. (2013), Reactive oxygen species in plant pathogenesis: the role of perylenequinone photosensitizers; Antioxid. Redox. Signal 19 970
- Guedes and Eriksson (2007), Photophysics, photochemistry, and reactivity: molecular aspects of perylenequinone reactions, Photochem. Photobiol. Sci. 6 1089
- Vandenbogaerde et al. (1998), Cytotoxicity and antiproliferative effect of hypericin and derivatives after photosensitization; Photochem. Photobiol., 67 119
- Morgan et al. (2009), Design, Synthesis, and Investigation of Protein Kinase C Inhibitors: Total Syntheses of (+)-Calphostin D, (+)-Phleichrome, Cercosporin, and New Photoactive Perylenequinones; J. Am. Chem. Soc., 131 9413
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Cercosporin (35082-49-6) is a perylenequinone from the fungus Cercospora kikuchii. Upon photo- activation, perylenequinones display almost universal toxicity to a broad variety of organisms.1 Exposure to visible and near-UV light activates this family of quinones to an excited triplet state that reacts with oxygen to form reactive oxygen species.2 Displays antiproliferative effects in various tumor cell lines.3 Selectively inhibits PKC (IC50=0.6-1.3 µM) over PKA and PPK.4
References/Citations:
- Daub et al. (2013), Reactive oxygen species in plant pathogenesis: the role of perylenequinone photosensitizers; Antioxid. Redox. Signal 19 970
- Guedes and Eriksson (2007), Photophysics, photochemistry, and reactivity: molecular aspects of perylenequinone reactions, Photochem. Photobiol. Sci. 6 1089
- Vandenbogaerde et al. (1998), Cytotoxicity and antiproliferative effect of hypericin and derivatives after photosensitization; Photochem. Photobiol., 67 119
- Morgan et al. (2009), Design, Synthesis, and Investigation of Protein Kinase C Inhibitors: Total Syntheses of (+)-Calphostin D, (+)-Phleichrome, Cercosporin, and New Photoactive Perylenequinones; J. Am. Chem. Soc., 131 9413
Related products
-
Elafibranor | PPARalpha/delta agonist
From $65.00CAS:923978-27-2Catalog Number:10-3901Activity:PPARalpha/delta agonistChemical Name:2-[2,6-Dimethyl-4-[(E)-3-(4-methylsulfanylphenyl)-3-oxoprop-1-enyl]phenoxy]-2-methylpropanoic acidAlternate Name:GFT505Molecular Weight:384.49Molecular Formula:C22H24O4SSolubility:Soluble in DMSO (up to at least 25 mg/ml).Physical Properties:Pale yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT -
AZ3146 | Mps1 kinase inhibitor
From $60.00CAS:1124329-14-1Catalog Number:10-4778Activity:Mps1 kinase inhibitorChemical Name:9-Cyclopentyl-2-[2-methoxy-4-(1-methylpiperidine-4-yl)oxyanilino]-7-methylpurin-8-oneMolecular Weight:452.56Molecular Formula:C24H32N6O3S2Solubility:Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to at least 25 mg/ml)Physical Properties:Off-white solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.Shipping Code:RT -
Pomalidomide | Cereblon ubiquitination inhibitor
From $50.00CAS:19171-19-8Catalog Number:10-2768Activity:Cereblon ubiquination inhibitorChemical Name:1,3-Dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline; 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamideMolecular Weight:273.24Molecular Formula:C13H11N3O4Solubility:Soluble in DMSO (up to 50 mg/ml).Physical Properties:Yellow solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
