Propargylglycine | H2S synthase inhibitor

Propargylglycine (64165-64-6) is an irreversible inhibitor of the hydrogen sulfide biosynthesis enzyme, cystathione-γ-lyase. It inhibits H2S production in rat liver preparations (IC50=55 μM) and inhibits the rise in plasma H2S in rats with hemorrhagic shock2. Propargylglycine reduces inflammation in a rodent carrageenan-induced hindpaw edema model3 and ameliorates gentamycin-induced nephrotoxicity1.

References/Citations
1) Dam et al. (2012), Inhibition of cystathione gamma-lyase and the biosynthesis of endogenous hydrogen sulphide ameliorares gentamicin-induced nephrotoxicity; Eur. J. Pharmacol., 685 165
2) Mok et al. (2004), Role of hydrogen sulphide in haemorrhagic shock in the rat: protective effect of inhibitors of hydrogen sulphide biosynthesis; Br. J. Pharmacol., 143 881
3) Bhatia et al. (2005),Hydrogen sulphide is a mediator of carrageenan-induced hindpaw edema in the rat; Br. J. Pharmacol., 145 141

Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size :

100 mg, 500 mg

Reviews

There are no reviews yet.

Be the first to review “Propargylglycine | H2S synthase inhibitor”

Your email address will not be published. Required fields are marked *

Product Inquiry

CAS:
64165-64-6
Catalog Number:
10-1366
Activity:
H2S synthase inhibitor
Chemical Name:
2-Amino-4-pentynoic acid
Molecular Weight:
113.12
Molecular Formula:
C5H7NO2
Solubility:
Soluble in DMSO (up to 10 mg/ml) or in Water (up tp 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT

Propargylglycine | H2S synthase inhibitor

$38.00$152.00

CAS:
64165-64-6
Catalog Number:
10-1366
Activity:
H2S synthase inhibitor
Chemical Name:
2-Amino-4-pentynoic acid
Molecular Weight:
113.12
Molecular Formula:
C5H7NO2
Solubility:
Soluble in DMSO (up to 10 mg/ml) or in Water (up tp 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT
  • 100 mg
  • 500 mg
Clear
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.