PSB-CB5 | GPR18 antagonist
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $75.00 | ||
| 25 mg | $300.00 |
PSB-CB5 (1627710-30-8) is a potent and selective GPR18 antagonist (IC50 = 0.279 μM) exhibiting >36-fold selectivity against GPR55 and CB1 and 14-fold selectivity against CB2.1 Inhibits N-arachidonylglycine-induced acrosomal exocytosis in human spermatozoa indicating that GPR18 may be involved in physiological processes of human spermatozoa.2
References/Citations:
1) Rempel et al. (2014), Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55; Med. Chem. Comm., 5 632
2) Flegel et al. (2016), Characterization of Non-Olfactory GPCRs in Human Sperm With a Focus on GPR18; Sci. Rep., 6 32255
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
PSB-CB5 (1627710-30-8) is a potent and selective GPR18 antagonist (IC50 = 0.279 μM) exhibiting >36-fold selectivity against GPR55 and CB1 and 14-fold selectivity against CB2.1 Inhibits N-arachidonylglycine-induced acrosomal exocytosis in human spermatozoa indicating that GPR18 may be involved in physiological processes of human spermatozoa.2
References/Citations:
1) Rempel et al. (2014), Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55; Med. Chem. Comm., 5 632
2) Flegel et al. (2016), Characterization of Non-Olfactory GPCRs in Human Sperm With a Focus on GPR18; Sci. Rep., 6 32255
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