PT-179 | Thalidomide analog molecular glue
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $70.00 | ||
| 25 mg | $250.00 |
PT-179 (2924858-25-1) is an orthogonal thalidomide analog that binds cereblon (CRBN: KD = 587 nM; pomalidomide KD = 500 nM) with greatly reduced off-target activity compared to pomalidomide. Pomalidomide induced differential expression of 1426 genes in MM.1S multiple myeloma cells compared to only 3 for PT-179. PT-179 is an interesting new tool for exploring CRBN-based therapeutics.
References/Citations:
- Nguyen et al. (2024), Proteolysis-targeting chimeras with reduced off-targets; Nat. Chem. 16 218
- Mercer et al. (2024), Continuous evolution of compact protein degradation tags regulated by selective molecular glues; Science 383 eadk4422
C17 H17N3O5
>98% HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
PT-179 (2924858-25-1) is an orthogonal thalidomide analog that binds cereblon (CRBN: KD = 587 nM; pomalidomide KD = 500 nM) with greatly reduced off-target activity compared to pomalidomide. Pomalidomide induced differential expression of 1426 genes in MM.1S multiple myeloma cells compared to only 3 for PT-179. PT-179 is an interesting new tool for exploring CRBN-based therapeutics.
References/Citations:
- Nguyen et al. (2024), Proteolysis-targeting chimeras with reduced off-targets; Nat. Chem. 16 218
- Mercer et al. (2024), Continuous evolution of compact protein degradation tags regulated by selective molecular glues; Science 383 eadk4422
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