PTP inhibitor III | Protein tyrosine phosphatase inhibitor
CAS:
29936-81-0
Catalog Number:
10-1586
Activity:
Protein tyrosine phosphatase inhibitor
Chemical Names:
2-(4-(2-Bromoacetyl)phenoxy)acetic acid
Molecular Weight:
273.08
Molecular Formula:
C10H9BrO4
Solubility:
Soluble in DMSO (25 mg/ml)
Physical Properties:
White solid
Purity:
90% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
Shipping Code:
RT
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $65.00 | ||
| 25 mg | $260.00 |
PTP inhibitor III (29936-81-0) inhibits a broad range of protein tyrosine phosphatases (PTPs). Binds covalently to the active site of the enzyme.1-2 Blocks SHP1-mediated dephosphorylation of TRPV1 in dorsal root ganglion neurons aggravating CFA-induced inflammatory pain.3
Rferences/Citations:
- Kanda et al. (2006), Glutaredoxin modulates platelet-derived growth factor-dependent cell signaling by regulating the redox status of low molecular weight protein-tyrosine phosphatase; J. Biol. Chem., 281 28518
- Popov et al. (2009), Vascular PTPs: current developments and challenges for exploitation in Type 2 diabetes-associated vascular dysfunction; Biochem. Biophys. Res. Commun., 389 1
- Xiao et al. (2015), Shp-1 dephosphorylates TRPV1 in dorsal root ganglion neurons and alleviates CFA-induced inflammatory pain in rats; Pain, 156 597
CAS:
29936-81-0
Catalog Number:
10-1586
Activity:
Protein tyrosine phosphatase inhibitor
Chemical Names:
2-(4-(2-Bromoacetyl)phenoxy)acetic acid
Molecular Weight:
273.08
Molecular Formula:
C10H9BrO4
Solubility:
Soluble in DMSO (25 mg/ml)
Physical Properties:
White solid
Purity:
90% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
Shipping Code:
RT
Safety Data Sheet:
N/A
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
PTP inhibitor III (29936-81-0) inhibits a broad range of protein tyrosine phosphatases (PTPs). Binds covalently to the active site of the enzyme.1-2 Blocks SHP1-mediated dephosphorylation of TRPV1 in dorsal root ganglion neurons aggravating CFA-induced inflammatory pain.3
Rferences/Citations:
- Kanda et al. (2006), Glutaredoxin modulates platelet-derived growth factor-dependent cell signaling by regulating the redox status of low molecular weight protein-tyrosine phosphatase; J. Biol. Chem., 281 28518
- Popov et al. (2009), Vascular PTPs: current developments and challenges for exploitation in Type 2 diabetes-associated vascular dysfunction; Biochem. Biophys. Res. Commun., 389 1
- Xiao et al. (2015), Shp-1 dephosphorylates TRPV1 in dorsal root ganglion neurons and alleviates CFA-induced inflammatory pain in rats; Pain, 156 597
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