In Nature Communications, Zhang et al. show that DJ001, a selective allosteric inhibitor of protein tyrosine phosphatase sigma (PTPσ), promotes hematopoietic stem cell (HSC) regeneration. Treatment of irradiated human HSCs with DJ001 promoted the regeneration of HSCs capable of multilineage in vivo repopulation. For a comprehensive portfolio of small molecule stem cell effectors visit https://bez.dlq.temporary.site/stem-cells-main/.
