PUGNAc | O-GlcNAcase inhibitor

CAS:
132489-69-1
Catalog Number:
10-2406
Activity:
O-GlcNAcase inhibitor
Chemical Name:
O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino-Z-N-phenylcarbamate
Molecular Weight:
353.33
Molecular Formula:
C15H19N3O7
Solubility:
Soluble in DMSO (up to 35 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$130.00
25 mg$490.00

PUGNAc (CAS 132489-69-1) is an O-GlcNAcase (O-GlcNAc-βN-acetylglucosaminidase) and β-hexosaminidase inhibitor (Ki=46 and 36 nM, respectively). A widely used tool for increasing cellular levels of O-GlcNAc.2 Protects cardiac function after trauma-hemorrhage which is mediated by increased protein O-GlcNAc levels.3 Induces insulin resistance in rat skeletal muscle.4

References/Citations:

1) Macauley et al. (2005), O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors; J. Biol. Chem., 280 25313
2) Kneass and Marchase (2005), Protein O-GlcNAc modulates motility-associated signaling intermediates in neutrophils; J. Biol. Chem., 280 14579
3) Zou et al. (2007), The protective effects of PUGNAC on cardiac function after trauma-hemorrhage are mediated via increased protein O-GlcNAc levels; Shock, 27 402
4) Arias et al. (2004), Prolonged incubation in PUGNAc results in increased protein O-Linked glycosylation and insulin resistance in rat skeletal muscle; Diabetes, 53 921

CAS:
132489-69-1
Catalog Number:
10-2406
Activity:
O-GlcNAcase inhibitor
Chemical Name:
O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino-Z-N-phenylcarbamate
Molecular Weight:
353.33
Molecular Formula:
C15H19N3O7
Solubility:
Soluble in DMSO (up to 35 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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