Size: | Price | Quantity | |
---|---|---|---|
5 mg | $130.00 | ||
25 mg | $490.00 |
PUGNAc (CAS 132489-69-1) is an O-GlcNAcase (O-GlcNAc-β–N-acetylglucosaminidase) and β-hexosaminidase inhibitor (Ki=46 and 36 nM, respectively). A widely used tool for increasing cellular levels of O-GlcNAc.2 Protects cardiac function after trauma-hemorrhage which is mediated by increased protein O-GlcNAc levels.3 Induces insulin resistance in rat skeletal muscle.4
References/Citations:
1) Macauley et al. (2005), O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors; J. Biol. Chem., 280 25313
2) Kneass and Marchase (2005), Protein O-GlcNAc modulates motility-associated signaling intermediates in neutrophils; J. Biol. Chem., 280 14579
3) Zou et al. (2007), The protective effects of PUGNAC on cardiac function after trauma-hemorrhage are mediated via increased protein O-GlcNAc levels; Shock, 27 402
4) Arias et al. (2004), Prolonged incubation in PUGNAc results in increased protein O-Linked glycosylation and insulin resistance in rat skeletal muscle; Diabetes, 53 921
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PUGNAc (CAS 132489-69-1) is an O-GlcNAcase (O-GlcNAc-β–N-acetylglucosaminidase) and β-hexosaminidase inhibitor (Ki=46 and 36 nM, respectively). A widely used tool for increasing cellular levels of O-GlcNAc.2 Protects cardiac function after trauma-hemorrhage which is mediated by increased protein O-GlcNAc levels.3 Induces insulin resistance in rat skeletal muscle.4
References/Citations:
1) Macauley et al. (2005), O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors; J. Biol. Chem., 280 25313
2) Kneass and Marchase (2005), Protein O-GlcNAc modulates motility-associated signaling intermediates in neutrophils; J. Biol. Chem., 280 14579
3) Zou et al. (2007), The protective effects of PUGNAC on cardiac function after trauma-hemorrhage are mediated via increased protein O-GlcNAc levels; Shock, 27 402
4) Arias et al. (2004), Prolonged incubation in PUGNAc results in increased protein O-Linked glycosylation and insulin resistance in rat skeletal muscle; Diabetes, 53 921
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