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Puromycin Aminonucleoside | Nephropathy inducer

CAS:
58-60-6
Catalog Number:
10-2101
Activity:
Nephropathy inducer
Alternate Names:
PAN
Chemical Name:
3′-Amino-3′-deoxy-N6,N6-dimethyladenosine
Molecular Weight:
294.32
Molecular Formula:
C12H18N6O3
Solubility:
Soluble in Water (up to 50 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.
Shipping Code:
RT

Puromycin aminonucleoside (58-60-6) is the nucleoside moiety of puromycin (Cat.# 10-2100) which does not inhibit protein synthesis or induce apoptosis.1 It acts as a glomerular epithelial cell toxin2 and as such is a useful tool for producing animal models of nephropathy3,4, or puromycin aminonucleoside nephrosis (1-2.5 mg/100g rat body weight)5. Active in vivo.

References/Citations:

1) Chow et al. (1995), Reevaluation of the role of de novo protein synthesis in rat thymocyte apoptosis; Exp. Cell Res., 216 149
2) Krishnamurti et al. (2001), Puromycin aminonucleoside suppresses integrin expression in cultured glomerular epithelial cells; J. Am. Soc. Nephrol., 12 758
3) Egashira et al. (2006), Tryptophan-niacin metabolism in rat with puromycin aminonucleoside-induced nephrosis; Int. J. Vitam. Nutr. Res., 76 28
4) Hagiwara et al. (2006), Mitochondrial dysfunction in focal segmental glomerulosclerosis of puromycin aminonucleoside nephrosis; Kidney Int., 69 1146
5) Lowenborg et al. (2000), Glomerular function and morphology in puromycin aminonucleoside nephropathy in rats; Nephrol. Dial. Transplant, 15 1547

Puromycin Aminonucleoside | Nephropathy inducer is also available in the Cellular Metabolism Library.
CAS:
58-60-6
Catalog Number:
10-2101
Activity:
Nephropathy inducer
Alternate Names:
PAN
Chemical Name:
3′-Amino-3′-deoxy-N6,N6-dimethyladenosine
Molecular Weight:
294.32
Molecular Formula:
C12H18N6O3
Solubility:
Soluble in Water (up to 50 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

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