PY-60 | YAP Activator

CAS:
 2765218-56-0
Catalog Number:
 10-3924

Available Options

SizePriceQuantity 
5mg$75.00
25mg$275.00

PY-60 (2765218-56-0) activates YAP transcriptional activity (EC50 = 1.6 µM) via delocalization of annexin A2 (ANXA2) from cell membranes leading to Hippo inactivation, a key controller of YAP.1 It was able to induce serum-free expansion of MCF10A cells and epidermal keratinocytes and their precursors ex vivo and in adult mice. PY-60 promoted regenerative repair of cutaneous wounds in pig and human models by enabling a pro-proliferative transcriptional program in keratinocytes and dermal cells that accelerated re-epithelization and regranulation of the wound bed.2

References/Citations:

  1. Shalhout, et al. (2021), YAP-dependent proliferation by a small molecule targeting annexin A2; Nat. Chem. Biol., 17 767
  2. Grzelak, et al. (2023), Pharmacological YAP activation promotes regenerative repair of cutaneous wounds; Proc. Natl. Acad. Sci. USA, 120 e2305085120
CAS:
2765218-56-0
Catalog Number:
10-3924
Activity:
YAP activator
Chemical Names:
5-Phenyl-N-[3-(1,3-thiazol-2-yl)propyl]-1,2-oxazole-3-carboxamide
Molecular Weight:
313.38
Molecular Formula:

C16H15N3O2S

Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:

>98% HPLC
NMR (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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