PY-60 | YAP Activator
Available Options
| Size | Price | Quantity | |
|---|---|---|---|
| 5mg | $75.00 | ||
| 25mg | $275.00 |
PY-60 (2765218-56-0) activates YAP transcriptional activity (EC50 = 1.6 µM) via delocalization of annexin A2 (ANXA2) from cell membranes leading to Hippo inactivation, a key controller of YAP.1 It was able to induce serum-free expansion of MCF10A cells and epidermal keratinocytes and their precursors ex vivo and in adult mice. PY-60 promoted regenerative repair of cutaneous wounds in pig and human models by enabling a pro-proliferative transcriptional program in keratinocytes and dermal cells that accelerated re-epithelization and regranulation of the wound bed.2
References/Citations:
- Shalhout, et al. (2021), YAP-dependent proliferation by a small molecule targeting annexin A2; Nat. Chem. Biol., 17 767
- Grzelak, et al. (2023), Pharmacological YAP activation promotes regenerative repair of cutaneous wounds; Proc. Natl. Acad. Sci. USA, 120 e2305085120
C16H15N3O2S
>98% HPLC
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
PY-60 (2765218-56-0) activates YAP transcriptional activity (EC50 = 1.6 µM) via delocalization of annexin A2 (ANXA2) from cell membranes leading to Hippo inactivation, a key controller of YAP.1 It was able to induce serum-free expansion of MCF10A cells and epidermal keratinocytes and their precursors ex vivo and in adult mice. PY-60 promoted regenerative repair of cutaneous wounds in pig and human models by enabling a pro-proliferative transcriptional program in keratinocytes and dermal cells that accelerated re-epithelization and regranulation of the wound bed.2
References/Citations:
- Shalhout, et al. (2021), YAP-dependent proliferation by a small molecule targeting annexin A2; Nat. Chem. Biol., 17 767
- Grzelak, et al. (2023), Pharmacological YAP activation promotes regenerative repair of cutaneous wounds; Proc. Natl. Acad. Sci. USA, 120 e2305085120
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