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Product Details

Pyocyanin | ROS generator

Pyocyanine (85-66-5), a redox-active phenazine produced by P. aeruginosa and other pathogens, is an electron receptor, which stimulates redox cycling in bacteria as well as in a variety of human cell lines. It enhances oxidative metabolism, which increases the formation of intracellular reactive oxygen species (ROS) via reduction of NADPH. Pyocyanine accelerates neutrophil apoptosis in vitro. Pyocyanine production by P. aeruginosa suppresses the acute inflammatory response by pathogen-driven acceleration of neutrophil apoptosis and associated reduction of local inflammation.

References/Citations
1) Rada and Leto (2013), Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas Aeruginosa airway infections; Trends Microbiol., 21 73
2) Reszka et al. (2012), Inactivation of the potent Pseudomonas aeruginosa cytotoxin pyocyanin by airway peroxidases and nitrite; Am. J. Physiol. Lung Cell Mol. Physiol., 302 L1044

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Pyocyanin | ROS generator | CAS 85-66-5

Catalog#  10-1507

$60.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
85-66-5
Catalog Number:
10-1507
Activity:
ROS generator
Alternate Names:
Pyocyanin, Sanasin, Sanazin
Chemical Name:
5-Methyl-1(5H)-phenazinone
Molecular Weight:
210.23
Molecular Formula:
C13H10N2O
Solubility:
Soluble in DMSO (up to 15 mg/ml).
Physical Properties:
Dark blue solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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