Pyr3 | TRPC3 Channel blocker
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $390.00 | ||
| 25 mg | $310.00 |
Pyr3 (1160514-60-2) is a selective blocker of the TRP canonical 3 channel (TRPC3)1 which can function as a receptor-operated channel2. A useful tool for dissecting GPCR-downstream signaling mechanisms.3 Pyr3 may be effective in reducing cardiac hypertrophy.2
References/Citations:
1) Kiyonaka et al. (2009), Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound; Proc. Natl. Acad. Sci. USA., 106 5400
2) Eder and Molkentin (2011), TRPC channels as effectors of cardiac hypertrophy; Circ. Res., 108 265
3) Sabourin et al. (2012), Activation of transient receptors potential canonical 3 (TRPC3)-mediated CA2+ entry by A1 adenosine receptor in cardiomyocytes disturbs atrioventricular conduction; J. Biol. Chem., 287 26688
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Pyr3 (1160514-60-2) is a selective blocker of the TRP canonical 3 channel (TRPC3)1 which can function as a receptor-operated channel2. A useful tool for dissecting GPCR-downstream signaling mechanisms.3 Pyr3 may be effective in reducing cardiac hypertrophy.2
References/Citations:
1) Kiyonaka et al. (2009), Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound; Proc. Natl. Acad. Sci. USA., 106 5400
2) Eder and Molkentin (2011), TRPC channels as effectors of cardiac hypertrophy; Circ. Res., 108 265
3) Sabourin et al. (2012), Activation of transient receptors potential canonical 3 (TRPC3)-mediated CA2+ entry by A1 adenosine receptor in cardiomyocytes disturbs atrioventricular conduction; J. Biol. Chem., 287 26688
Related products
-
EPA free acid | omega-3 fatty acid
From $30.00CAS:10417-94-4Catalog Number:10-1313Activity:omega-3 fatty acidAlternate Names:Eicosapentaenoic acidChemical Name:Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic acid (20:5, n-3)Molecular Weight:302.46Molecular Formula:C20H30O2Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 100 mg/ml).Physical Properties:Colorless to pale yellow oilPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year as supplied (unopened). After opening, EPA must be stored under inert gas at -80°C. Solutions in DMSO or ethanol should also be stored under inert gas and may be kept at -80°C for up to 2 months.Shipping Code:RT -
Isradipine | L-type Ca channel blocker
From $64.00CAS:75695-93-1Catalog Number:10-1202Activity:L-type Ca channel blockerChemical Name:4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, methyl, 1-methylethyl diesterMolecular Weight:371.4Molecular Formula:C19H21N3O5Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml).Physical Properties:Yellow solidPurity:99% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchsae as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Phenoxybenzamine HCl | Calmodulin antagonist
From $30.00CAS:63-92-3Catalog Number:10-1237Activity:Calmodulin antagonistChemical Name:N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochlorideMolecular Weight:340.29Molecular Formula:C18H22ClNO HClSolubility:Soluble in DMSO (up to 50 mg/ml), or in Water (up to 15 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
