Pyrintegrin | ß1-integrin agonist
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $200.00 |
Pyrintegrin (1228445-38-2) is a β1-integrin agonist that promotes survival of human embryonic stem cells following enzymatic dissociation by enhancing cell-ECM-mediated integrin activity.1 It induces soft tissue formation from transplanted or endogenous cells via stimulation of adipogenesis and may have potential in soft tissue therapeutic reconstruction and augmentation2, It protects podocytes from LPS-induced injury in vivo3. A very useful tool for exploring the involvement of β1-integrin signaling in cellular physiology.4,5
References/Citations:
- Xu et al. (2010) Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules; Proc. Natl. Acad. Sci. USA 107 8129
- Shah et al. (2017) Pyrintegrin Induces Soft Tissue Formation by Transplanted or Endogenous Cells; Sci. Rep. 7 36402
- Lee et al. (2015) A Podocyte-Based Automated Screening Assay Identifies Protective Small Molecules; J. Am. Soc. Nephrol. 26 2741
- Li et al. (2021) Extracellular matrix protein laminin β1 regulates pain sensitivity and anxiodepression-like behaviors in mice; J. Clin. Invest. 131 e146323
- Li et al. (2025) Mechanistic insights into the treatment of pulmonary fibrosis with bioactive components from traditional chinese medicine via matrix stiffness-mediated EMT; Phytomedicine 136 e156266
C23H25N5O3S
>98% HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Pyrintegrin (1228445-38-2) is a β1-integrin agonist that promotes survival of human embryonic stem cells following enzymatic dissociation by enhancing cell-ECM-mediated integrin activity.1 It induces soft tissue formation from transplanted or endogenous cells via stimulation of adipogenesis and may have potential in soft tissue therapeutic reconstruction and augmentation2, It protects podocytes from LPS-induced injury in vivo3. A very useful tool for exploring the involvement of β1-integrin signaling in cellular physiology.4,5
References/Citations:
- Xu et al. (2010) Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules; Proc. Natl. Acad. Sci. USA 107 8129
- Shah et al. (2017) Pyrintegrin Induces Soft Tissue Formation by Transplanted or Endogenous Cells; Sci. Rep. 7 36402
- Lee et al. (2015) A Podocyte-Based Automated Screening Assay Identifies Protective Small Molecules; J. Am. Soc. Nephrol. 26 2741
- Li et al. (2021) Extracellular matrix protein laminin β1 regulates pain sensitivity and anxiodepression-like behaviors in mice; J. Clin. Invest. 131 e146323
- Li et al. (2025) Mechanistic insights into the treatment of pulmonary fibrosis with bioactive components from traditional chinese medicine via matrix stiffness-mediated EMT; Phytomedicine 136 e156266
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