Q-VD-OPh | Pan-specific caspase inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 1 mg | $80.00 | ||
| 5 mg | $300.00 |
Q-VD-OPh (1135695-98-5) is a potent and highly effective pan-caspase inhibitor with potent antiapoptotic activity which is not toxic to cells.1 Displays protective effects on brain damage and bacterial infection in a murine MCAO stroke model.2 Switches doxorubicin-induced apoptosis to an alternative default cell death mode marked by increased expression of senescence markers.3 Blocks staurosporin-induced differentiation of embryonic stem cells to cardiomyocytes.4 Trophoblasts treated with ceramide and Q-VD-OPh undergo necroptosis.5
References/Citations:
1) Caserta et al. (2003), Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties; Apoptosis, 8 345
2) Braun et al. (2007), Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPH; Exp. Neurol., 206 183
3) Rebbaa et al. (2003), Caspase inhibition switches doxorubicin-induced apoptosis to senescence; Oncogene, 22 2805
4) Bulatovic et al. (2015), Sublethal caspase activation promotes generation of cardiomyocytes from embryonic stem cells; PLoS One, 10 e0120176
5) Bailey et al. (2017), Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis; Cell Death Dis., 8 e2590
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Q-VD-OPh (1135695-98-5) is a potent and highly effective pan-caspase inhibitor with potent antiapoptotic activity which is not toxic to cells.1 Displays protective effects on brain damage and bacterial infection in a murine MCAO stroke model.2 Switches doxorubicin-induced apoptosis to an alternative default cell death mode marked by increased expression of senescence markers.3 Blocks staurosporin-induced differentiation of embryonic stem cells to cardiomyocytes.4 Trophoblasts treated with ceramide and Q-VD-OPh undergo necroptosis.5
References/Citations:
1) Caserta et al. (2003), Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties; Apoptosis, 8 345
2) Braun et al. (2007), Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPH; Exp. Neurol., 206 183
3) Rebbaa et al. (2003), Caspase inhibition switches doxorubicin-induced apoptosis to senescence; Oncogene, 22 2805
4) Bulatovic et al. (2015), Sublethal caspase activation promotes generation of cardiomyocytes from embryonic stem cells; PLoS One, 10 e0120176
5) Bailey et al. (2017), Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis; Cell Death Dis., 8 e2590
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