Quinacrine HCl | Antiprotozoan / Anticancer
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 20 mg | $30.00 | ||
| 100 mg | $50.00 |
Quinacrine HCl (69-05-6) is an antiprotozoan drug used for malaria and giardiasis and has recently been investigated in treating lupus, as an anticancer agent, inflammation, and as a female sterilization agent.1 It has been found to have synergistic effects with vorinostat in the treatment of T-cell acute lymphoblastic leukemia via mitophagy blockage and an increase in ROS.2 Quinacrine displayed antitumor effects in an intestinal cancer mouse model and HCT116 p53-/- xenografts via reduction in Chk1/2 expression and cell death induction in the G2-M phase.3 It promotes autophagic cell death in ovarian cancer cells via downregulation of p62/SQSTM1.4 Quinacrine is also an inhibitor of phospholipase A2.5
References/Citations:
1) Ehsanian et al. (2011), Beyond DNA binding – a review of the potential mechanisms mediating quinacrine’s therapeutic activities in parasitic infections, inflammation, and cancers; Cell Commun. Signal. 9 13
2) Jing et al. (2018), Vorinostat and quinacrine have synergistic effects in T-cell acute lymphoblastic leukemia through reactive oxygen species increase and mitophagy inhibition; Cell Death Disease 9 589
3) Park et al. (2018), Therapeutic Effect of Quinacrine, an Antiprotozoan Drug, by Selective Suppression of p-CHK1/2 in p53-Negative Malignant Cancers; Mol. Cancer Res. 16 935
4) Khurana et al. (2015), Quinacrine promotes autophagic cell death and chemosensitivity in ovarian cancer and attenuates tumor growth; Oncotarget 6 36354
5) Chan et al. (1982), Biphasic modulation of platelet phospholipase A2 activity and platelet aggregation by mepacrine (quinacrine); Biochim. Biophys. Acta 713 170
NMR (Conforms)
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Product Data Sheet:
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Quinacrine HCl (69-05-6) is an antiprotozoan drug used for malaria and giardiasis and has recently been investigated in treating lupus, as an anticancer agent, inflammation, and as a female sterilization agent.1 It has been found to have synergistic effects with vorinostat in the treatment of T-cell acute lymphoblastic leukemia via mitophagy blockage and an increase in ROS.2 Quinacrine displayed antitumor effects in an intestinal cancer mouse model and HCT116 p53-/- xenografts via reduction in Chk1/2 expression and cell death induction in the G2-M phase.3 It promotes autophagic cell death in ovarian cancer cells via downregulation of p62/SQSTM1.4 Quinacrine is also an inhibitor of phospholipase A2.5
References/Citations:
1) Ehsanian et al. (2011), Beyond DNA binding – a review of the potential mechanisms mediating quinacrine’s therapeutic activities in parasitic infections, inflammation, and cancers; Cell Commun. Signal. 9 13
2) Jing et al. (2018), Vorinostat and quinacrine have synergistic effects in T-cell acute lymphoblastic leukemia through reactive oxygen species increase and mitophagy inhibition; Cell Death Disease 9 589
3) Park et al. (2018), Therapeutic Effect of Quinacrine, an Antiprotozoan Drug, by Selective Suppression of p-CHK1/2 in p53-Negative Malignant Cancers; Mol. Cancer Res. 16 935
4) Khurana et al. (2015), Quinacrine promotes autophagic cell death and chemosensitivity in ovarian cancer and attenuates tumor growth; Oncotarget 6 36354
5) Chan et al. (1982), Biphasic modulation of platelet phospholipase A2 activity and platelet aggregation by mepacrine (quinacrine); Biochim. Biophys. Acta 713 170
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