(R)-GNE-140 | Lactate dehydrogenase inhibitor

CAS:
 2003234-63-5
Catalog Number:
 10-4355
GNE-140 chemical structure

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(R)-GNE-140 (2003234-63-5) is a  potent (IC50’s: LDHA = 3 nM, LDHB = 5 nM, LDHC = 5 nM) pan-lactate dehydrogenase inhibitor.1 It significantly decreased lactate levels in vivo, although the effects were transient.  GNE-140 suppressed lactic acid production, severely stunted glucose utilization, and impeded the anaerobic glycolytic pathway in MDA-MB-231 triple negative breast cancer cells.2

References/Citations:

  1. Boudreau et al. (2016), Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition; Nat. Chem. Biol. 12 779
  2. Mazzio (2021), Triple Isozyme Lactic Acid Dehydrogenase Inhibition in Fully Viable MDA-MB-231 Cells Induces Cytostatic Effects That Are Not Reversed by Exogenous Lactic Acid; Biomolecules 11 1751
(R)-GNE-140 supplier, 2003234-63-5, GNE-140, GNE-140 supplier, GNE140, lactate dehydrogenase inhibitor, LDHA inhibitor, LDHB inhibitor
CAS:
2003234-63-5
Catalog Number:
10-4355
Activity:
Lactate dehydrogenase inhibitor
Chemical Names:
(2R)-5-(2-Chlorophenyl)sulfanyl-4-hydroxy-2-(4-morpholin-4-ylphenyl)-2-thiophen-3-yl-1,3-dihydropyridin-6-one
Molecular Weight:
499.04
Molecular Formula:

C25H23ClN3O3S2

Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white to pale orange solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

Download Safety Data Sheet

Product Data Sheet:

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

(R)-GNE-140 (2003234-63-5) is a  potent (IC50’s: LDHA = 3 nM, LDHB = 5 nM, LDHC = 5 nM) pan-lactate dehydrogenase inhibitor.1 It significantly decreased lactate levels in vivo, although the effects were transient.  GNE-140 suppressed lactic acid production, severely stunted glucose utilization, and impeded the anaerobic glycolytic pathway in MDA-MB-231 triple negative breast cancer cells.2

References/Citations:

  1. Boudreau et al. (2016), Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition; Nat. Chem. Biol. 12 779
  2. Mazzio (2021), Triple Isozyme Lactic Acid Dehydrogenase Inhibition in Fully Viable MDA-MB-231 Cells Induces Cytostatic Effects That Are Not Reversed by Exogenous Lactic Acid; Biomolecules 11 1751

Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21

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