Raltitrexed | Thymidylate synthase inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $50.00 | ||
| 50 mg | $165.00 |
Raltitrexed (112887-68-0) is an inhibitor of thymidylate synthase with significantly increased potency in many cancer cell lines when compared with 5-fluorouracil.1,2 It is also an inhibitor of the methyltransferase G9a (IC50 = 120 nM) and decreased Aß aggregates in C. elegans indicating therapeutic potential for the treatment of Alzheimer’s disease.3
References/Citations:
- Marsham et al. (1991) Quinazoline Antifolate Thymidylate Synthase Inhibitors: Heterocyclic Benzoyl Ring Modifications; J. Med. Chem. 34 1594
- Jackman et al. (1995) ZD1694(Tomudex): A New Thymidylate Synthase Inhibitor with Activity in Colorectal Cancer; Eur. J. Cancer 31A 1277
- Jana et al. (2023) Repurposing of Raltitrexed as an Effective G91/EHMT2 Inhibitor and Promising Anti-Alzheimer’s Agent; ACS Med. Chem. Lett. 14 1531
C21H22N4O6S
>98% by HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Raltitrexed (112887-68-0) is an inhibitor of thymidylate synthase with significantly increased potency in many cancer cell lines when compared with 5-fluorouracil.1,2 It is also an inhibitor of the methyltransferase G9a (IC50 = 120 nM) and decreased Aß aggregates in C. elegans indicating therapeutic potential for the treatment of Alzheimer’s disease.3
References/Citations:
- Marsham et al. (1991) Quinazoline Antifolate Thymidylate Synthase Inhibitors: Heterocyclic Benzoyl Ring Modifications; J. Med. Chem. 34 1594
- Jackman et al. (1995) ZD1694(Tomudex): A New Thymidylate Synthase Inhibitor with Activity in Colorectal Cancer; Eur. J. Cancer 31A 1277
- Jana et al. (2023) Repurposing of Raltitrexed as an Effective G91/EHMT2 Inhibitor and Promising Anti-Alzheimer’s Agent; ACS Med. Chem. Lett. 14 1531
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