Size : | Price | Quantity | |
---|---|---|---|
5 mg | $50.00 | ||
25 mg | $175.00 |
Rbin-1 (328023-11-6) is potent (GI50 = 136 nM) and reversible inhibitor of eukaryotic ribosome assembly. The biochemical target of Rbin-1 is Midasin (Mdn1), an essential AAA+ protein. Blocking of Mdn1 by Rbin-1 inhibits the processing of pre-60S particles, important pre-ribosomal subunits produced in the nucleolus.
References/Citations:
1) Kawashime et al. (2016), Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis; Cell 167 512
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Rbin-1 (328023-11-6) is potent (GI50 = 136 nM) and reversible inhibitor of eukaryotic ribosome assembly. The biochemical target of Rbin-1 is Midasin (Mdn1), an essential AAA+ protein. Blocking of Mdn1 by Rbin-1 inhibits the processing of pre-60S particles, important pre-ribosomal subunits produced in the nucleolus.
References/Citations:
1) Kawashime et al. (2016), Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis; Cell 167 512
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