Rbin-1 | Eukaryotic ribosome assembly inhibitor

CAS:
328023-11-6
Catalog Number:
10-4606
Activity:
Eukaryotic ribosome assembly inhibitor
Chemical Name:
3-[(2-Methyl-2-propen-1-yl)sulfanyl]-5H-[1,2,4]triazino[5,6-b]indole
Molecular Weight:
256.33
Molecular Formula:
C13H12N4S
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
Pale yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
5 mg$50.00
25 mg$175.00

Rbin-1 (328023-11-6) is potent (GI50 = 136 nM) and reversible inhibitor of eukaryotic ribosome assembly.  The biochemical target of Rbin-1 is Midasin (Mdn1), an essential AAA+ protein.  Blocking of Mdn1 by Rbin-1 inhibits the processing of pre-60S particles, important pre-ribosomal subunits produced in the nucleolus.

References/Citations:

1) Kawashime et al. (2016), Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis; Cell 167 512

CAS:
328023-11-6
Catalog Number:
10-4606
Activity:
Eukaryotic ribosome assembly inhibitor
Chemical Name:
3-[(2-Methyl-2-propen-1-yl)sulfanyl]-5H-[1,2,4]triazino[5,6-b]indole
Molecular Weight:
256.33
Molecular Formula:
C13H12N4S
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
Pale yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

20% OFF

For Postdoc
Customers!