Autophagy

Autophagy is a catabolic process that enables a cell to avoid death by selectively degrading unnecessary or dysfunctional cytosolic components for recycling into energy and essential building blocks. It is employed in response to normal (for example, development) and abnormal (for example, cancer) stresses, which can be either internal (such as protein aggregates or cellular homeostasis) or external (such as nutrient limitation). More recently, autophagy has also been shown to be used as a cell death pathway [autophagic cell death (ACD)], such as in tumor suppression.

Inducers

  • PF-543 HCl | Sphingosine kinase-1 inhibitor
    CAS:
    1706522-79-3
    Catalog Number:
    10-4998
  • Oligomycin A | Mitochondrial ATPase inhibitor
    CAS:
    579-13-5
    Catalog Number:
    10-5368
    Activity:
    Mitochondrial ATPase inhibitor
    Source:
    Streptomyces sp.
    Molecular Weight:
    791.06
    Molecular Formula:
    C45H74O11
    Solubility:
    Soluble in DMSO (up to 300 mg/ml); Ethanol (up to 200 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • PLX4720 | Mutant B-Raf inhibitor
    CAS:
    918505-84-7
    Catalog Number:
    10-5113
    Activity:
    Mutant B-Raf inhibitor
    Chemical Names:
    N-[3-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
    Molecular Weight:
    413.82
    Molecular Formula:
    C17H14ClF2N3O3S
    Solubility:
    Soluble in DMSO (30 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Urolithin A | Mitophagy Inducer
    CAS:
    1143-70-0
    Catalog Number:
    10-3722
    Activity:
    Mitophagy inducer
    Chemical Names:
    3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one; 2′,7-Dihydroxy-3,4-benzocoumarin
    Molecular Weight:
    228.20
    Molecular Formula:
    C13H8O4
    Solubility:
    Soluble in DMSO (50 mg/ml)
    Physical Properties:
    Pale yellow solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Stavudine | HIV reverse transcriptase inhibitor
    CAS:
    3056-17-5
    Catalog Number:
    10-1266
    Activity:
    HIV reverse transcriptase inhibitor
    Chemical Names:
    2’,3’-Didehydro-3’-deoxythymidine
    Alternate Name:
    BMY 27857; d4T
    Molecular Weight:
    224.22
    Molecular Formula:
    C10H12N2O4
    Solubility:
    Soluble in DMSO (20 mg/ml); water (20 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Inducers Products

Inhibitors

  • Vacuolin-1 | Autophagy/PIKfyve inhibitor
    CAS:
    351986-85-1
    Catalog Number:
    10-5151
  • Rotenone | Mitochondrial Complex I Inhibitor
    CAS:
    83-79-4
    Catalog Number:
    10-2277
    Activity:
    Mitochondrial Complex I Inhibitor
    Chemical Names:
    (2R,6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one
    Alternate Name:
    NSC-26285; Nicouline
    Molecular Weight:
    394.42
    Molecular Formula:
    C23H22O6
    Solubility:
    Soluble in DMSO (50 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    Room Temperature
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Autophinib | Autophagy inhibitor
    CAS:
    1644443-47-9
    Catalog Number:
    10-3476
    Activity:
    Autophagy inhibitor
    Chemical Names:
    6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-4-pyrimidinamine
    Molecular Weight:
    346.73
    Molecular Formula:
    C14H11ClN6O3
    Solubility:
    Soluble in DMSO (30 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Cepharanthine | Autophagy inhibitor/Antiviral
    CAS:
    481-49-2
    Catalog Number:
    10-5074
    Activity:
    Autophagy inhibitor/Antiviral
    Chemical Names:
    O-Methylcepharanoline; NSC623442
    Molecular Weight:
    606.71
    Molecular Formula:
    C37H38N2O6
    Solubility:
    Soluble in DMSO (35 mg/mL) or ethanol (20 mg/mL)
    Physical Properties:
    Pale yellow solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Autogramin-2 | Autophagy blocker / GRAMD1A inhibitor
    CAS:
    2375541-45-8
    Catalog Number:
    10-4439
    Activity:
    Autophagy blocker / GRAMD1A inhibitor
    Chemical Name:

    t-Butyl 2-[(4-propan-2-yloxybenzoyl)amino]-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-5-carboxylate

    Molecular Weight:
    417.53
    Molecular Formula:
    C21H27N3O4S
    Solubility:
    Soluble in DMSO (up t0 25 mg/ml) or in Ethanol (up to 25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Inhibitors Products

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Plymouth Meeting, PA USA
1-855-FOCUS21

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