G proteins

G proteins are fundamental signaling components of the cell. G proteins are GTPases, functioning as guanine nucleotide-binding and -hydrolyzing proteins. In the inactive state they are bound to GDP; when they bind GTP (in some cases facilitated by GPCRs), they become active, stimulating and amplifying myriad signaling pathways that ultimately regulate cell growth, differentiation, and migration.

Home >> Biochemical Targets >> G proteins

Activators

ADP-ribosylation

Veliparib 2HCl | PARP 1/2 inhibitor

CAS:

912445-05-7

Catalog Number:

10-2419

Activity:

PARP 1/2 inhibitor

Chemical Names:

2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide dihydrochloride

Alternate Name:

ABT-888

Molecular Weight:

317.22

Molecular Formula:

C₁₃H₁₆N₄O·2HCl

Solubility:

Soluble in DMSO (30 mg/ml); water (40 mg/ml)

Physical Properties:

White solid

Purity:

>98% TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or water may be stored at -20°C for up to 3 months.

Shipping Code:

UPF-1069 | PARP-2 inhibitor

CAS:

1048371-03-4

Catalog Number:

10-3779

Activity:

PPAR-2 inhibitor

Chemical Name:

5-(2-Oxo-3-phenylethoxy)-1(2H)-isoquinolinone

Molecular Weight:

279.29

Molecular Formula:

C₁₇H₁₃NO₃

Solubility:

Soluble in DMSO (up to 40 mg/ml).

Physical Properties:

Off-white solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

-20°

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Shipping Code:

Rucaparib phosphate | PARP1 inhibitor

CAS:

459868-92-9

Catalog Number:

10-3321

Activity:

PARP1 inhibitor

Chemical Name:

8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one

Alternate Name:

AG-14699; PF01367338

Molecular Weight:

421.36

Molecular Formula:

C₁₉H₁₈FN₃O • H₃PO₄

Solubility:

Soluble in DMSO (up to 25 mg/ml).

Physical Properties:

Yellow solid

Purity:

98% by HPLC
NMR (Conforms)

Storage Temperature:

-20°

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Shipping Code:

Inhibitors

CCG-4986 | RGS4 inhibitor

CAS:

7134-19-2

Catalog Number:

10-1431

Activity:

RGS4 inhibitor

Chemical Names:

Methyl-N-[(4-chlorophenyl)sulfonyl]-4-nitrobenzenesulfinimidoate

Molecular Weight:

374.81

Molecular Formula:

C₁₃H₁₁ClN₂O₅S₂

Solubility:

Soluble in DMSO (60 mg/ml); Ethanol (5 mg/ml with warming)

Physical Properties:

White solid

Purity:

>98% TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Shipping Code:

YM-254890 | Gαq inhibitor

CAS:

568580-02-9

Catalog Number:

10-1590

Activity:

Gαq inhibitor

Source:

Isolated from Chromobacterium sp.

Molecular Weight:

960.1

Molecular Formula:

C₄₆H₆₉N₇O₁₅

Solubility:

Soluble in DMSO (up to 10 mg/ml)

Physical Properties:

White or off-white lyophilized solid

Purity:

95% by HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Shipping Code:

Small G proteins

SJ6986 | GSPT1 molecular glue

CAS:

2765625-93-0

Catalog Number:

10-3933

MRTX849 | Covalent KRAS^G12C Inhibitor

CAS:

2326521-71-3

Catalog Number:

10-4985

AMG 510 |Covalent KRAS^G12C Inhibitor

CAS:

2296729-00-3

Catalog Number:

10-3930

G proteins

Activators

ADP-ribosylation

Veliparib 2HCl | PARP 1/2 inhibitor

UPF-1069 | PARP-2 inhibitor

Rucaparib phosphate | PARP1 inhibitor

Inhibitors

CCG-4986 | RGS4 inhibitor

YM-254890 | Gαq inhibitor

Small G proteins

SJ6986 | GSPT1 molecular glue

MRTX849 | Covalent KRAS^G12C Inhibitor

AMG 510 |Covalent KRAS^G12C Inhibitor

Uncouplers

Other

Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21

G proteins

Activators

ADP-ribosylation

Inhibitors

Small G proteins

Uncouplers

Other

Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules Plymouth Meeting, PA USA1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21