Repaglinide | Kir6 blocker
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 20 mg | $30.00 | ||
| 100 mg | $95.00 |
Repaglinide (135062-02-1) is a blocker of the ATP-sensitive potassium channel Kir6 with hypoglycemic activity.1 Clinically useful antidiabetic agent. It displays 30-fold selectivity for pancreatic Kir6.2/SUR1 over cardiac Kir6.1/SUR2B and Kir6/SUR2A channels.2 Repaglinide displayed neuroprotective effects in Huntington disease3, Parkinson’s disease4, and ALS5 via blockade of the DREAM-ATF6 interaction.
References/Citations:
- Mark and Grell (1997), Hypoglycaemic effects of the novel antidiabetic agent repaglinide in rats and dogs; Br. J. Pharmacol. 121 1597
- Stephan et al. (2006), Selectivity of repaglinide and glibenclamide for the pancreatic over the cardiovascular K(ATP) channels; Diabetologia 49 2039
- Naranjo et al. (2016), Activating transcription factor 6 Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease; J. Clin. Invest. 126 627
- Motawi et al. (2022), Repaglinide Elicits a Neuroprotective Effect in Rotenone-Induced Parkin’s Disease in Rats: Emphasis on Targeting the DREAM-ER Stress BiP/ATF6/CHOP Trajectory and Activation of Mitophagy; ACS Chem. Neurosci. 14 180
- Gonzalo-Gobernado et al. (2023), Repaglinide Induces ATF6 Processing and Neuroprotection in Transgenic SOD1G93A Mice; Int. J. Mol. Sci. 24 15783
C27H36N2O4
>98% by TLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Repaglinide (135062-02-1) is a blocker of the ATP-sensitive potassium channel Kir6 with hypoglycemic activity.1 Clinically useful antidiabetic agent. It displays 30-fold selectivity for pancreatic Kir6.2/SUR1 over cardiac Kir6.1/SUR2B and Kir6/SUR2A channels.2 Repaglinide displayed neuroprotective effects in Huntington disease3, Parkinson’s disease4, and ALS5 via blockade of the DREAM-ATF6 interaction.
References/Citations:
- Mark and Grell (1997), Hypoglycaemic effects of the novel antidiabetic agent repaglinide in rats and dogs; Br. J. Pharmacol. 121 1597
- Stephan et al. (2006), Selectivity of repaglinide and glibenclamide for the pancreatic over the cardiovascular K(ATP) channels; Diabetologia 49 2039
- Naranjo et al. (2016), Activating transcription factor 6 Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease; J. Clin. Invest. 126 627
- Motawi et al. (2022), Repaglinide Elicits a Neuroprotective Effect in Rotenone-Induced Parkin’s Disease in Rats: Emphasis on Targeting the DREAM-ER Stress BiP/ATF6/CHOP Trajectory and Activation of Mitophagy; ACS Chem. Neurosci. 14 180
- Gonzalo-Gobernado et al. (2023), Repaglinide Induces ATF6 Processing and Neuroprotection in Transgenic SOD1G93A Mice; Int. J. Mol. Sci. 24 15783
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