Retinoic acid | Retinoid RAR agonist
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 50 mg | $30.00 | ||
| 500 mg | $60.00 |
all-trans-Retinoic acid (302-79-4) a metabolite of Vitamin A, is an endogenous ligand for the retinoic acid receptor (RAR). The binding of retinoic acid to the RAR and retinoid X (RXR) heterodimer causes conformation changes in RAR that affects the binding of other proteins that regulate the growth and differentiation of a variety of both normal and malignant cells.1 Retinoic acid promotes differentiation of embryonic stem cells (ESCs) into a variety of cell types in vitro.2-4
References/Citations:
1) Allenby (1993), Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acid; Proc. Natl. Acad. Sci. USA, 90 30
2) Dani et . (1997) Differentiation of embryonic stem cells into adipocytes in vitro; J. Cell Sci. 110 1279
3) Hu (2009) Differentiation Of Spinal Motor Neurons From Pluripotent Human Stem Cells; Nat. Protoc., 4 1295
4) Sasai (2002) Generation of dopaminergic neurons from embryonic stem cells J. Neurol., 249 II 41
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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all-trans-Retinoic acid (302-79-4) a metabolite of Vitamin A, is an endogenous ligand for the retinoic acid receptor (RAR). The binding of retinoic acid to the RAR and retinoid X (RXR) heterodimer causes conformation changes in RAR that affects the binding of other proteins that regulate the growth and differentiation of a variety of both normal and malignant cells.1 Retinoic acid promotes differentiation of embryonic stem cells (ESCs) into a variety of cell types in vitro.2-4
References/Citations:
1) Allenby (1993), Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acid; Proc. Natl. Acad. Sci. USA, 90 30
2) Dani et . (1997) Differentiation of embryonic stem cells into adipocytes in vitro; J. Cell Sci. 110 1279
3) Hu (2009) Differentiation Of Spinal Motor Neurons From Pluripotent Human Stem Cells; Nat. Protoc., 4 1295
4) Sasai (2002) Generation of dopaminergic neurons from embryonic stem cells J. Neurol., 249 II 41
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