RMC-7977 | KRAS inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 1 mg | $80.00 | ||
| 5 mg | $295.00 |
RMC-7977 (2765082-12-8) is broad spectrum inhibitor of both mutant and wild-type KRAS, NRAS, and HRAS variants.1 It binds with high affinity to cyclophilin A (KD = 195 nM) creating a binary complex that has high affinity for the active state of KRAS (KD = 85 nM for G12V). Active in in vivo xenograft models of NSCLC, CRC, and PDAC.1,2,3 RMC-7977 was able to overcome resistance to the KRASG12D selective inhibitor MRTX1133.1
References/Citations:
- Holderfield et al. (2024), Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy; Nature 629 919
- Wasko et al. (2024), Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer; Nature 629 927
- Araujo et al. (2024), Mechanisms of Response and Tolerance to Active RAS Inhibition in KRAS-Mutant Non-Small Cell Lung Cancer; Cancer Discov. 14 2183
C47H60N8O6S
>98% HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
RMC-7977 (2765082-12-8) is broad spectrum inhibitor of both mutant and wild-type KRAS, NRAS, and HRAS variants.1 It binds with high affinity to cyclophilin A (KD = 195 nM) creating a binary complex that has high affinity for the active state of KRAS (KD = 85 nM for G12V). Active in in vivo xenograft models of NSCLC, CRC, and PDAC.1,2,3 RMC-7977 was able to overcome resistance to the KRASG12D selective inhibitor MRTX1133.1
References/Citations:
- Holderfield et al. (2024), Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy; Nature 629 919
- Wasko et al. (2024), Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer; Nature 629 927
- Araujo et al. (2024), Mechanisms of Response and Tolerance to Active RAS Inhibition in KRAS-Mutant Non-Small Cell Lung Cancer; Cancer Discov. 14 2183
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
