Ro 31-6045 | MAP Kinase inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 1 mg | $50.00 | ||
| 5 mg | $205.00 |
Ro 31-6045 (113963-68-1) is a bis indolylmaleimide derivative that is a potent inhibitor of the mitogen-stimulated protein kinase p70 (S6K) acting independently of its upstream activator mTOR.1 Does not inhibit PKC (at concentrations <100 mM) and therefore may be used as a negative control for bisindolylmaleimide PKC inhibitors2 such as GF 109203X3 and other structurally related inhibitors4.
References/Citations:
1) Marmy-Conus et al. (2002), Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling; FEBS Lett., 519 135
2) Harmon et al. (1997), Bisindolylmaleimide protein-kinase C inhibitors delay in the decline in DNA synthesis in mouse hair follicle organ cultures; Skin Pharmacol., 10 71
3) Toullec et al. (1991), The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C; J. Biol. Chem., 266 15771
4) Davis et al. (1992), Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides; J. Med. Chem., 35 177
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Ro 31-6045 (113963-68-1) is a bis indolylmaleimide derivative that is a potent inhibitor of the mitogen-stimulated protein kinase p70 (S6K) acting independently of its upstream activator mTOR.1 Does not inhibit PKC (at concentrations <100 mM) and therefore may be used as a negative control for bisindolylmaleimide PKC inhibitors2 such as GF 109203X3 and other structurally related inhibitors4.
References/Citations:
1) Marmy-Conus et al. (2002), Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling; FEBS Lett., 519 135
2) Harmon et al. (1997), Bisindolylmaleimide protein-kinase C inhibitors delay in the decline in DNA synthesis in mouse hair follicle organ cultures; Skin Pharmacol., 10 71
3) Toullec et al. (1991), The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C; J. Biol. Chem., 266 15771
4) Davis et al. (1992), Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides; J. Med. Chem., 35 177
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