Ro 41-5253 | RARα antagonist
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $75.00 | ||
| 25 mg | $295.00 |
Ro 41-5253 (144092-31-9) is a selective RARα antagonist.1 Binds RARα without inducing transcription or influencing RAR/RXR heterodimerization and DNA binding.2 Ro 415253 inhibits proliferation and induces apoptosis in a variety of cell lines/types. Cell Permeable.
References/Citations:
1) Apfel et al. (1992), A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects; Proc. Natl. Acad. Sci. USA, 89 7129
2) Toma et al. (1998), RARα antagonist Ro 41-5253 inhibits proliferation and induces apoptosis in breast-cancer cell lines; Int. J. Cancer, 78 86
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Ro 41-5253 (144092-31-9) is a selective RARα antagonist.1 Binds RARα without inducing transcription or influencing RAR/RXR heterodimerization and DNA binding.2 Ro 415253 inhibits proliferation and induces apoptosis in a variety of cell lines/types. Cell Permeable.
References/Citations:
1) Apfel et al. (1992), A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects; Proc. Natl. Acad. Sci. USA, 89 7129
2) Toma et al. (1998), RARα antagonist Ro 41-5253 inhibits proliferation and induces apoptosis in breast-cancer cell lines; Int. J. Cancer, 78 86
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